ArticlePLoS genetics2011
The fission yeast stress-responsive MAPK pathway promotes meiosis via the phosphorylation of Pol II CTD in response to environmental and feedback cues.
Article in PLoS genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 38 citations in OpenAlex.
- Cyclin-dependent kinases: Masters of the eukaryotic universe.Wiley interdisciplinary reviews. RNA · 2023Review
- Functional genomic analysis ofiScience · 2023Article
- Proteome analysis ofBiochemistry and biophysics reports · 2020Article
- Multiple roles of CTDK-I throughout the cell.Cellular and molecular life sciences : CMLS · 2019Review
- Progression of Meiosis Is Coordinated by the Level and Location of MAPK Activation Via OGR-2 inGenetics · 2019Article
- Computational modelling of meiotic entry and commitment.Scientific reports · 2018Article
- Salt Stress and CTD PHOSPHATASE-LIKE4 Mediate the Switch between Production of Small Nuclear RNAs and mRNAs.The Plant cell · 2017Article
- Salinity-Induced Palmella Formation Mechanism in Halotolerant AlgaeFrontiers in plant science · 2017Article
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- Article
- The SrkA Kinase Is Part of the SakA Mitogen-Activated Protein Kinase Interactome and Regulates Stress Responses and Development in Aspergillus nidulans.Eukaryotic cell · 2015Article
- Sexual development of Schizosaccharomyces pombe is induced by zinc or iron limitation through Ecl1 family genes.Molecular genetics and genomics : MGG · 2015Article
- Modulation of RNA polymerase II phosphorylation downstream of pathogen perception orchestrates plant immunity.Cell host & microbe · 2014Article
- Individual letters of the RNA polymerase II CTD code govern distinct gene expression programs in fission yeast.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- On the computational ability of the RNA polymerase II carboxy terminal domain.Communicative & integrative biology · 2014Article
- RNA polymerase II C-terminal domain: Tethering transcription to transcript and template.Chemical reviews · 2013Review
- A novel factor Iss10 regulates Mmi1-mediated selective elimination of meiotic transcripts.Nucleic acids research · 2013Article
- PNUTS/PP1 regulates RNAPII-mediated gene expression and is necessary for developmental growth.PLoS genetics · 2013Article
- Synthetically engineered rpb1 alleles altering RNA polymerase II carboxy terminal domain phosphorylation induce discrete morphogenetic defects in Schizosaccharomyces pombe.Communicative & integrative biology · 2013Article
- Mate and fuse: how yeast cells do it.Open biology · 2013Review
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The RRM-type RNA-binding protein Mei2 is a master regulator of meiosis in fission yeast, in which it stabilizes meiosis-specific mRNAs by blocking their destruction. Artificial activation of Mei2 can provoke the entire meiotic process, and it is suspected that Mei2 may do more than the stabilization of meiosis-specific mRNAs. In our current study using a new screening system, we show that Mei2 genetically interacts with subunits of CTDK-I, which phosphorylates serine-2 residues on the C-terminal domain of RNA polymerase II (Pol II CTD). Phosphorylation of CTD Ser-2 is essential to enable the robust transcription of ste11, which encodes an HMG-type transcription factor that regulates the expression of mei2 and other genes necessary for sexual development. CTD Ser-2 phosphorylation increases under nitrogen starvation, and the stress-responsive MAP kinase pathway, mediated by Wis1 MAPKK and Sty1 MAPK, is critical for this stress response. Sty1 phosphorylates Lsk1, the catalytic subunit of CTDK-I. Furthermore, a feedback loop stemming from activated Mei2 to Win1 and Wis4 MAPKKKs operates in this pathway and eventually enhances CTD Ser-2 phosphorylation and ste11 transcription. Hence, in addition to starting meiosis, Mei2 functions to reinforce the commitment to it, once cells have entered this process. This study also demonstrates clearly that the stress-responsive MAP kinase pathway can modulates gene expression through phosphorylation of Pol II CTD.
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