ArticleScience (New York, N.Y.)2011
Improving validation practices in "omics" research.
Article in Science (New York, N.Y.), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
93 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Cell-Free Nucleic Acids for Early Diagnosis of Acute Ischemic Stroke: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2025Pooled it
- Associations of network-derived metabolite clusters with prevalent type 2 diabetes among adults of Puerto Rican descent.BMJ open diabetes research & care · 2021Pooled it
- External validation of multivariable prediction models: a systematic review of methodological conduct and reporting.BMC medical research methodology · 2014Pooled it
- Knowledge integration in cancer: current landscape and future prospects.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2013Pooled it
- Characterizing metabolomic and proteomic changes in depression: a systematic analysis.Molecular psychiatry · 2025Article
- Applications of chromatographic methods in metabolomics: A review.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2024Review
- Omics-based biomarkers as useful tools in metabolic dysfunction-associated steatotic liver disease clinical practice: How far are we?World journal of gastroenterology · 2024Review
- Proteome-wide Analyses Identified Cortical Proteins Associated With Resilience for Varied Cognitive Abilities.Neurology · 2024Article
- Metabolomics studies in common multifactorial eye disorders: a review of biomarker discovery for age-related macular degeneration, glaucoma, diabetic retinopathy and myopia.Frontiers in molecular biosciences · 2024Review
- Decoding the exposome: data science methodologies and implications in exposome-wide association studies (ExWASs).Exposome · 2024Article
- Transparent reporting of multivariable prediction models developed or validated using clustered data (TRIPOD-Cluster): explanation and elaboration.BMJ (Clinical research ed.) · 2023Article
- Metabolomics analysis of urine from patients with alcohol-associated liver disease reveals dysregulated caffeine metabolism.American journal of physiology. Gastrointestinal and liver physiology · 2023Article
- Rehabilomics: A state-of-the-art review of framework, application, and future considerations.Frontiers in neurology · 2023Review
- Advances, obstacles, and opportunities for machine learning in proteomics.Cell reports. Physical science · 2022Article
- Article
- Recent Progress and Future Direction for the Application of Multiomics Data in Clinical Liver Transplantation.Journal of clinical and translational hepatology · 2022Review
- Multi-Staged Data-Integrated Multi-Omics Analysis for Symptom Science Research.Biological research for nursing · 2021Article
- Designing deep learning studies in cancer diagnostics.Nature reviews. Cancer · 2021Review
- The changing face ofMedEdPublish (2016) · 2021Article
- Recruiting Control Participants into Stroke Biomarker Studies.Translational stroke research · 2020Review
33 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
"Omics" research poses acute challenges regarding how to enhance validation practices and eventually the utility of this rich information. Several strategies may be useful, including routine replication, public data and protocol availability, funding incentives, reproducibility rewards or penalties, and targeted repeatability checks.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.