ArticleInfection and immunity2012
Differential gene expression in mice infected with distinct Toxoplasma strains.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Unifying Virulence Evaluation inFrontiers in cellular and infection microbiology · 2022Review
- Early immune responses and parasite tissue distribution in mice experimentally infected with oocysts of either archetypal or non-archetypal genotypes ofParasitology · 2021Article
- Article
- AcuteFrontiers in immunology · 2018Article
- Excretory/secretory products from two Fasciola hepatica isolates induce different transcriptional changes and IL-10 release in LPS-activated bovine "BOMA" macrophages.Parasitology research · 2017Article
- Evidence for host genetic regulation of altered lipid metabolism in experimental toxoplasmosis supported with gene data mining results.PloS one · 2017Article
- Transcriptional profiling of Toll-like receptor 2-deficient primary murine brain cells during Toxoplasma gondii infection.PloS one · 2017Article
- Long-Term Relationships: the Complicated Interplay between the Host and the Developmental Stages of Toxoplasma gondii during Acute and Chronic Infections.Microbiology and molecular biology reviews : MMBR · 2015Review
- AMA1-deficient Toxoplasma gondii parasites transiently colonize mice and trigger an innate immune response that leads to long-lasting protective immunity.Infection and immunity · 2015Article
- Calomys callosus chronically infected by Toxoplasma gondii clonal type II strain and reinfected by Brazilian strains is not able to prevent vertical transmission.Frontiers in microbiology · 2015Article
- Dual transcriptional profiling of mice and Toxoplasma gondii during acute and chronic infection.BMC genomics · 2014Article
- GRA25 is a novel virulence factor of Toxoplasma gondii and influences the host immune response.Infection and immunity · 2014Article
- MicroRNA-132 dysregulation in Toxoplasma gondii infection has implications for dopamine signaling pathway.Neuroscience · 2014Article
- Toxoplasma gondii and neuropsychiatric diseases: strain hypothesis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2013Article
- A genome-wide siRNA screen to identify host factors necessary for growth of the parasite Toxoplasma gondii.PloS one · 2013Article
- Toxoplasma gondii infection, from predation to schizophrenia: can animal behaviour help us understand human behaviour?The Journal of experimental biology · 2013Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxoplasma gondii is the causative agent of toxoplasmosis in human and animals. In a mouse model, T. gondii strains can be divided into three groups, including the virulent, intermediately virulent, and nonvirulent. The clonal type I, II, and III T. gondii strains belong to these three groups, respectively. To better understand the basis of virulence phenotypes, we investigated mouse gene expression responses to the infection of different T. gondii strains at day 5 after intraperitoneal inoculation with 500 tachyzoites. The transcriptomes of mouse peritoneal cells showed that 1,927, 1,573, and 1,009 transcripts were altered more than 2-fold by type I, II, and III infections, respectively, and that the majority of altered transcripts were shared. Overall transcription patterns were similar in type I and type II infections, and both had greater changes than infection with type III. Quantification of parasite burden in mouse spleens showed that the burden with type I infection was 1,000 times higher than that of type II and that the type II burden was 20 times higher than that of type III. Fluorescence-activated cell sorting revealed that type I and II infections had comparable macrophage populations, and both were higher than the population with type III infection. In addition, type I infection had a higher percentage of neutrophils than type II and III infections. Taken together, these results suggested that there is a common gene expression response to T. gondii infection in mice. This response is further modified by parasite strain-specific factors that determine their distinct virulence phenotypes.
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