Evidence map›Paper›PMID 22144484›Full record

ReviewInfection and immunity2012

Molecular mechanisms that mediate colonization of Shiga toxin-producing Escherichia coli strains.

Mauricio J Farfan, Alfredo G Torres

Open access · bronzeAbstract readReview
In one paragraph

Review in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers.

0numbers the graph read from it
0cells of the map it votes in
71citing papers in PubMed
8.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

71 citing papers in PubMed, 156 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Comparative genomics of Shiga toxin-producingFrontiers in veterinary science · 2025
    Article
  7. Review
  8. ThemSphere · 2024
    Article
  9. Article
  10. Safety Properties ofFoods (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Shiga Toxin-ProducingMicroorganisms · 2022
    Review
  16. Article
  17. Article
  18. Article
  19. Toxins · 2021
    Review
  20. Nonfimbrial Adhesin Mutants Reveal DivergentInternational journal of microbiology · 2021
    Article

11 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Mauricio J FarfanCentro de Estudios Moleculares, Departamento de Pediatría, Hospital Dr. Luis Calvo Mackenna, Facultad de Medicina, Universidad de Chile, Santiago, Chile.
Alfredo G Torres
Hospital Luis Calvo Mackenna · CLThe University of Texas Medical Branch at Galveston · US

Funding

Long Polar Fimbriae of Attaching and Effacing Escherichia coliR01AI079154 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI TORRES, ALFREDO G · 2009 to 2013
$1.9M
NIAID NIH HHS 5R01AI079154-03NIAID NIH HHS R01 AI079154
6 · The paper itself

Abstract

Shiga toxin-producing Escherichia coli (STEC) is a group of pathogens which cause gastrointestinal disease in humans and have been associated with numerous food-borne outbreaks worldwide. The intimin adhesin has been considered for many years to be the only colonization factor in these strains. However, the rapid progress in whole-genome sequencing of different STEC serotypes has accelerated the discovery of other adhesins (fimbrial and afimbrial), which have emerged as important contributors to the intestinal colonization occurring during STEC infection. This review summarizes recent progress to identify and characterize, at the molecular level, novel adhesion and colonization factors in STEC strains, with an emphasis on their contribution to virulence traits, their host-pathogen interactions, the regulatory mechanisms controlling their expression, and their role as targets eliciting immune responses in the host.

Indexed as

Bacterial AdhesionAdhesins, BacterialEscherichia coli InfectionsGastrointestinal TractGene Expression Regulation, BacterialHost-Pathogen InteractionsHumansImmunity, MucosalShiga-Toxigenic Escherichia coliVirulenceAdhesins, Bacterial

Identifiers

PMID22144484
PMCPMC3294676
OpenAlexW2115489314

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.