ArticleInfection and immunity2012
Critical role of LuxS in the virulence of Campylobacter jejuni in a guinea pig model of abortion.
Article in Infection and immunity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 43 citations in OpenAlex.
- Article
- Small RNA CjNC110 regulates the activated methyl cycle to enable optimal chicken colonization bymSphere · 2025Article
- Natural Antimicrobial Mixtures Disrupt Attachment and Survival ofFoods (Basel, Switzerland) · 2023Article
- Fecal Microbiota Transplantation ReducesAntibiotics (Basel, Switzerland) · 2023Article
- Review
- Mutagenic strategies against luxS gene affect the early stage of biofilm formation of Campylobacter jejuni.Journal of applied genetics · 2022Article
- 1,8-Cineole inhibits biofilm formation and bacterial pathogenicity by suppressingFrontiers in pharmacology · 2022Article
- Molecular Mechanisms of Campylobacter Biofilm Formation and Quorum Sensing.Current topics in microbiology and immunology · 2021Review
- Role ofInfection and immunity · 2020Article
- Small Noncoding RNA CjNC110 Influences Motility, Autoagglutination, AI-2 Localization, Hydrogen Peroxide Sensitivity, and Chicken Colonization in Campylobacter jejuni.Infection and immunity · 2020Article
- Modulation ofMicroorganisms · 2020Article
- (-)-α-Pinene reduces quorum sensing and Campylobacter jejuni colonization in broiler chickens.PloS one · 2020Article
- Article
- Clinical relevance of infections with zoonotic and human oral species of Campylobacter.Journal of microbiology (Seoul, Korea) · 2016Review
- A single nucleotide change in mutY increases the emergence of antibiotic-resistant Campylobacter jejuni mutants.The Journal of antimicrobial chemotherapy · 2015Article
- From deep-sea volcanoes to human pathogens: a conserved quorum-sensing signal in Epsilonproteobacteria.The ISME journal · 2015Article
- A comparative analysis of methylome profiles of Campylobacter jejuni sheep abortion isolate and gastroenteric strains using PacBio data.Frontiers in microbiology · 2014Article
- Phenotypes of Campylobacter jejuni luxS mutants are depending on strain background, kind of mutation and experimental conditions.PloS one · 2014Article
- Quorum sensing dependent phenotypes and their molecular mechanisms in Campylobacterales.European journal of microbiology & immunology · 2012Review
- LuxS and quorum-sensing in Campylobacter.Frontiers in cellular and infection microbiology · 2012Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Previous studies on Campylobacter jejuni have demonstrated the role of LuxS in motility, cytolethal distending toxin production, agglutination, and intestinal colonization; however, its direct involvement in virulence has not been reported. In this study, we demonstrate a direct role of luxS in the virulence of C. jejuni in two different animal hosts. The IA3902 strain, a highly virulent sheep abortion strain recently described by our laboratory, along with its isogenic luxS mutant and luxS complement strains, was inoculated by the oral route into both a pregnant guinea pig virulence model and a chicken colonization model. In both cases, the IA3902 luxS mutant demonstrated a complete loss of ability to colonize the intestinal tract. In the pregnant model, the mutant also failed to induce abortion, while the wild-type strain was highly abortifacient. Genetic complementation of the luxS gene fully restored the virulent phenotype in both models. Interestingly, when the organism was inoculated into guinea pigs by the intraperitoneal route, no difference in virulence (abortion induction) was observed between the luxS mutant and the wild-type strain, suggesting that the defect in virulence following oral inoculation is likely associated with a defect in colonization and/or translocation of the organism out of the intestine. These studies provide the first direct evidence that LuxS plays an important role in the virulence of C. jejuni using an in vivo model of natural disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.