Evidence map›Paper›PMID 22144297›Full record

ReviewMethods in molecular biology (Clifton, N.J.)2012

Neurogenic astrocytes and their glycoconjugates: not just "glue" anymore.

Dennis A Steindler

Abstract readReview
In one paragraph

Review in Methods in molecular biology (Clifton, N.J.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Dennis A SteindlerDepartment of Neuroscience, The Evelyn F. and William L. McKnight Brain Institute, The University of Florida, Gainesville, FL, USA. steindler@mbi.ufl.edu

Funding

STEM/PROGENITOR CELL PROTECTION FOR PARKINSON'S DISEASER01NS055165 · NINDS · UNIVERSITY OF FLORIDA · PI STEINDLER, DENNIS A. · 2007 to 2011
$1.6M
NINDS NIH HHS NS055165NINDS NIH HHS R01 NS055165
6 · The paper itself

Abstract

Cells with certain attributes of very immature astroglial cells and their radial precursors can act as stem and/or progenitor cells during developmental and persistent neurogenesis. Neural stem/progenitor cells both express and are affected by a variety of developmentally regulated macromolecules and growth factors, and such signaling or recognition molecules are being uncovered through extensive genomic and proteomic studies, as well as tested using in vitro/in vivo cell growth bioassays. Glycosylated molecules are appreciated as distinct signaling molecules during morphogenesis in a variety of tissues and organs, with glycoconjugates (glycoproteins, glycolipids, and glycosaminoglycans) serving as mediators for the interactions of cells with each other and their substrates, to confer growth and differentiation cues to precursor cells in search of identity. Neurogenic astrocytes and associated glycoconjugates, especially extracellular matrix molecules, are discussed in the context of neurogenesis and stem/progenitor cell growth, fate choice, and differentiation.

Indexed as

AnimalsAstrocytesCell CommunicationCell DifferentiationCell ProliferationExtracellular MatrixGlycoconjugatesHumansNeural Stem CellsNeurogenesisGlycoconjugates

Identifiers

PMID22144297
PMCPMC4438309

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.