ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2012
High thymidine kinase 1 (TK1) expression is a predictor of poor survival in patients with pT1 of lung adenocarcinoma.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 33 citations in OpenAlex.
- Unraveling lung cancer dynamics: a new metabolic signature improving the prediction of recurrence in resected lung adenocarcinoma.Journal of translational medicine · 2026Article
- Integrated Bioinformatics Investigation of Novel Biomarkers of Uterine Leiomyosarcoma Diagnosis and Outcome.Journal of personalized medicine · 2023Article
- Development of a Novel Recombinant Full-Length IgY Monoclonal Antibody against Human Thymidine Kinase 1 for Automatic Chemiluminescence Analysis on a Sandwich Biotin-Streptavidin Platform for Early Tumour Discovery.Journal of immunology research · 2023Article
- Multi-Omic Data Improve Prediction of Personalized Tumor Suppressors and Oncogenes.Frontiers in genetics · 2022Article
- Review
- Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level.Scientific reports · 2019Article
- IntratumoralEJNMMI research · 2019Article
- Clinical significance and diagnostic capacity of serum TK1, CEA, CA 19-9 and CA 72-4 levels in gastric and colorectal cancer patients.Journal of Cancer · 2018Article
- Serological TK1 predict pre-cancer in routine health screenings of 56,178 people.Cancer biomarkers : section A of Disease markers · 2018Article
- RNA-seq of serial kidney biopsies obtained during progression of chronic kidney disease from dogs with X-linked hereditary nephropathy.Scientific reports · 2017Article
- Anticancer activity of a thymidine quinoxaline conjugate is modulated by cytosolic thymidine pathways.BMC cancer · 2015Article
- Screening of critical genes in lung adenocarcinoma via network analysis of gene expression profile.Pathology oncology research : POR · 2014Article
- Identification of genes and candidate agents associated with pancreatic cancer.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Inhibition effect of a custom peptide on lung tumors.PloS one · 2014Article
- Thymidine kinase 1 is a better prognostic marker than Ki-67 for pT1 adenocarcinoma of the lung.International journal of clinical and experimental medicine · 2014Article
- Serum thymidine kinase 1 levels predict cancer-free survival following neoadjuvant, surgical and adjuvant treatment of patients with locally advanced breast cancer.Molecular and clinical oncology · 2013Article
- Thymidine kinase 1 as a diagnostic tumor marker is of moderate value in cancer patients: A meta-analysis.Biomedical reports · 2013Article
- Nuclear TK1 expression is an independent prognostic factor for survival in pre-malignant and malignant lesions of the cervix.BMC cancer · 2013Article
- MicroRNAs at the human 14q32 locus have prognostic significance in osteosarcoma.Orphanet journal of rare diseases · 2013Article
- The proliferation marker thymidine kinase 1 in clinical use.Molecular and clinical oncology · 2013Review
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, we explore the association of thymidine kinase 1 (TK1) expression in tumour tissues with clinical pathological parameters and prognosis in patients with pathological T1 (pT1) lung adenocarcinoma. The expression of TK1 was studied by immunohistochemistry techniques in 80 patients with surgically resected pT1 lung adenocarcinoma, retrospectively and at >10-year follow-up. Compared to patients with low TK1 expression [labelling index (LI) <25.0%], patients with high TK1 expression (LI ≥ 25.0%) showed significantly increased lymphatic/vascular permeation and lymph node involvement and higher stromal invasion grade and pathological stage, and a greater number of patients had a tumour size of 2.1 to 3.0 cm. The 5-year survival and the mortality during follow-up for patients with high TK1 expression were significantly worse than that of patients with low TK1 expression. The prognoses of the cases with grade 0, grade 1 and grade 2 stromal invasions were similar and were better than those of cases with grade 3. In patients with stromal invasion grade 3, the 5-year survival and the mortality during follow-up were significantly worse for patients with high TK1 compared to patients with low TK1 expression. Univariate analyses showed that stromal invasion and TK1 expression were significant prognostic factors, while in the multivariate analysis, TK1 expression and tumour stage were found to be independent prognostic factors, but not stromal invasion. This is the first study showing that TK1 expression in combination with stromal invasion is a more reliable prognostic factor than stromal invasion classification itself in patients with pT1 lung adenocarcinoma. TK1 expression enables a further classification of the patients and opens opportunities for improved treatment outcome.
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