ArticleGenetics2012
Multiple routes to subfunctionalization and gene duplicate specialization.
Article in Genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Pheromone Gene Diversification and the Evolution of Courtship Glands in Plethodontid Salamanders.Journal of molecular evolution · 2021Article
- Genome-wide identification of GMP genes in Rosaceae and functional characterization of FaGMP4 in strawberry (Fragaria × ananassa).Genes & genomics · 2021Article
- Constructive Neutral Evolution 20 Years Later.Journal of molecular evolution · 2021Review
- Identification of Anthocyanins-Related Glutathione S-Transferase (GST) Genes in the Genome of Cultivated Strawberry (International journal of molecular sciences · 2020Article
- A likelihood ratio test for changes in homeolog expression bias.BMC bioinformatics · 2019Article
- DuplicatedPeerJ · 2019Article
- Evolution of new regulatory functions on biophysically realistic fitness landscapes.Nature communications · 2017Article
- Article
- Long-term asymmetrical acceleration of protein evolution after gene duplication.Genome biology and evolution · 2014Article
- Faster evolving Drosophila paralogs lose expression rate and ubiquity and accumulate more non-synonymous SNPs.Biology direct · 2014Article
- The evolution of genetic architectures underlying quantitative traits.Proceedings. Biological sciences · 2013Article
- Elucidating the evolutionary history and expression patterns of nucleoside phosphorylase paralogs (vegetative storage proteins) in Populus and the plant kingdom.BMC plant biology · 2013Article
- Both positive and negative selection pressures contribute to the polymorphism pattern of the duplicated human CYP21A2 gene.PloS one · 2013Article
- Article
- Gene functional trade-offs and the evolution of pleiotropy.Genetics · 2012Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene duplication is arguably the most significant source of new functional genetic material. A better understanding of the processes that lead to the stable incorporation of gene duplications into the genome is important both because it relates to interspecific differences in genome composition and because it can shed light on why some classes of gene are more prone to duplication than others. Typically, models of gene duplication consider the periods before duplication, during the spread and fixation of a new duplicate, and following duplication as distinct phases without a common underlying selective environment. I consider a scenario where a gene that is initially expressed in multiple contexts can undergo mutations that alter its expression profile or its functional coding sequence. The selective regime that acts on the functional output of the allele copies carried by an individual is constant. If there is a potential selective benefit to having different coding sequences expressed in each context, then, regardless of the constraints on functional variation at the single-locus gene, the waiting time until a gene duplication is incorporated goes down as population size increases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.