Evidence map›Paper›PMID 22143867›Full record

ReviewIntegrative biology : quantitative biosciences from nano to macro2012

What yeast and cardiomyocytes share: ultradian oscillatory redox mechanisms of cellular coherence and survival.

David Lloyd, Sonia Cortassa, Brian O'Rourke, Miguel A Aon

Abstract readReview
In one paragraph

Review in Integrative biology : quantitative biosciences from nano to macro, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. New tunes from the heart.Biophysical journal · 2015
    Article
  9. Article
  10. Minutes, days and years: molecular interactions among different scales of biological timing.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014
    Review
  11. Review
  12. Article
  13. Article
  14. Mitochondrial network energetics in the heart.Wiley interdisciplinary reviews. Systems biology and medicine
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

David LloydSchool of Biosciences, Cardiff University, Museum Avenue, Cardiff CF10 3AT Wales, UK. lloydd@cardiff.ac.uk
Sonia Cortassa
Brian O'Rourke
Miguel A Aon

Funding

STRUCTURE OF MITOCHONDRIAL K+ CHANNELSP01HL081427 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI VAN EYK, JENNIFER E · 2005 to 2009
$11.2M
ENERGETIC REGULATION OF CARDIAC ION CHANNELSR37HL054598 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI O'ROURKE, BRIAN · 2005 to 2014
$3.7M
Mechanisms Underlying Mitrochondrial Dysfunction in the Diabetic HeartR01HL091923 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI AKAR, FADI GABRIEL, AON, MIGUEL ANTONIO · 2009 to 2012
$1.9M
Mechanisms of ROS Balance and Cardiac Energy Metabolism in Diabetes MellitusR21HL106054 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CORTASSA, SONIA DEL CARMEN · 2011 to 2012
$451k
NHLBI NIH HHS P01 HL081427NHLBI NIH HHS P01HL081427NHLBI NIH HHS R01 HL091923NHLBI NIH HHS R01-HL091923-01NHLBI NIH HHS R21 HL106054NHLBI NIH HHS R21HL106054NHLBI NIH HHS R37 HL054598NHLBI NIH HHS R37HL54598
6 · The paper itself

Abstract

The coherent and robust, yet sensitively adaptable, nature of organisms is an astonishing phenomenon that involves massive parallel processing and concerted network performance at the molecular level. Unravelling the dynamic complexities of the living state underlines the essential operation of ultradian oscillations, rhythms and clocks for the establishment and maintenance of functional order simultaneously on fast and slower timescales. Non-invasive monitoring of respiration, mitochondrial inner membrane potentials, and redox states (especially those of NAD(P)H, flavin, and the monochlorobimane complex of glutathione), even after more than 50 years research, continue to provide both new insights and biomedical applications. Experiments with yeast and in cardiac cells reveal astonishing parallels and similarities in their dynamic biochemical organization.

Indexed as

AnimalsBiological ClocksCircadian RhythmMitochondriaMyocytes, CardiacOxidation-ReductionReactive Oxygen SpeciesYeastsReactive Oxygen Species

Identifiers

PMID22143867
PMCPMC3348865

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.