ArticleProceedings of the National Academy of Sciences of the United States of America2011
Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 39 citations in OpenAlex.
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- Regulators and Conductors of Immunity: Natural Immune System in Health and Autoimmunity.International journal of molecular sciences · 2025Review
- Borrelia spielmanii-Associated Neuroborreliosis in Patient Receiving Rituximab, Belgium.Emerging infectious diseases · 2025Article
- Identification of collaborative cross mouse strains permissive to Salmonella enterica serovar Typhi infection.Scientific reports · 2023Article
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- Lyme Disease: Diversity ofHealthcare (Basel, Switzerland) · 2020Article
- Classification and Staging of Morgellons Disease: Lessons from Syphilis.Clinical, cosmetic and investigational dermatology · 2020Article
- Humanized Mouse Model Mimicking Pathology of Human Tuberculosis forFrontiers in immunology · 2019Article
- Case report: persistently seronegative neuroborreliosis in an immunocompromised patient.BMC infectious diseases · 2018Article
- Humanized Mice as Unique Tools for Human-Specific Studies.Archivum immunologiae et therapiae experimentalis · 2018Review
- The use of humanized mice for studies of viral pathogenesis and immunity.Current opinion in virology · 2018Review
- Relapsing feverInternational journal of general medicine · 2018Article
- Detection of tick-borne infection in Morgellons disease patients by serological and molecular techniques.Clinical, cosmetic and investigational dermatology · 2018Article
- Humoral Immunity in Mice Transplanted with Hematopoietic Stem Cells Derived from Human Umbilical Cord Blood Recapitulates That of Human Infants.Stem cells and development · 2017Article
- Host Immune Evasion by Lyme and Relapsing Fever Borreliae: Findings to Lead Future Studies forFrontiers in immunology · 2017Review
- Human B-1 and B-2 B Cells Develop from Lin-CD34+CD38lo Stem Cells.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Variable Major Proteins as Targets for Specific Antibodies against Borrelia miyamotoi.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Distinctions among Circulating Antibody-Secreting Cell Populations, Including B-1 Cells, in Human Adult Peripheral Blood.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- B-1 lymphocytes in mice and nonhuman primates.Annals of the New York Academy of Sciences · 2015Review
- Translating transitions - how to decipher peripheral human B cell development.Journal of biomedical research · 2015Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Rodents are natural reservoirs for a variety of species of Borrelia that cause relapsing fever (RF) in humans. The murine model of this disease recapitulates many of the clinical manifestations of the human disease and has revealed that T cell-independent antibody responses are required to resolve the bacteremic episodes. However, it is not clear whether such protective humoral responses are mounted in humans. We examined Borrelia hermsii infection in human hematopoietic stem cell-engrafted nonobese diabetic/SCID/IL-2Rγ(null) mice: "human immune system mice" (HISmice). Infection of these mice, which are severely deficient in lymphoid and myeloid compartments, with B. hermsii resulted in persistent bacteremia. In contrast, this infection in HISmice resulted in recurrent episodes of bacteremia, the hallmark of RF. The resolution of the primary episode of bacteremia was concurrent with the generation of B. hermsii-specific human IgM. Remarkably, HISmice generated antibody responses to the B. hermsii outer-membrane protein Factor H binding protein A. Sera from humans infected by B. hermsii have a similar reactivity, and studies in mice have shown that this response is generated by the B1b cell subset. HISmice contain several B-cell subsets, including those with the phenotype CD20(+)CD27(+)CD43(+)CD70(-), a proposed human equivalent of mouse B1 cells. Reduction of B cells by administration of anti-human CD20 antibody resulted in diminished anti-B. hermsii responses and persistent bacteremia in HISmice. These data indicate that analysis of B. hermsii infection in HISmice will serve as a model in which to study the cellular and molecular mechanisms involved in controlling human RF.
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