ArticleMedicina oral, patologia oral y cirugia bucal2012
The role of mast cells on angiogenesis in oral squamous cell carcinoma.
Article in Medicina oral, patologia oral y cirugia bucal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 50 citations in OpenAlex.
- Lymphangiogenesis in Odontogenic Keratocysts Compared with Dentigerous Cysts.Journal of dentistry (Shiraz, Iran) · 2024Article
- Article
- Evaluation of Mast Cell Density using CD117 antibody and Microvessel Density Using CD34 Antibody in Different Grades of Oral Squamous Cell Carcinoma.Asian Pacific journal of cancer prevention : APJCP · 2020Article
- Article
- Mast Cells and Blood Vessels Profile in Oral Carcinogenesis: An Immunohistochemistry Study.Asian Pacific journal of cancer prevention : APJCP · 2020Observational
- Mediators of Inflammation - A Potential Source of Biomarkers in Oral Squamous Cell Carcinoma.Journal of immunology research · 2018Review
- The role of mast cells in oral squamous cell carcinoma.Contemporary oncology (Poznan, Poland) · 2017Review
- Mast Cell-Targeted Strategies in Cancer Therapy.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2016Review
- Mast Cells: Key Players in the Shadow in Oral Inflammation and in Squamous Cell Carcinoma of the Oral Cavity.BioMed research international · 2016Review
- Cd34 and Mast Cell Analysis in Normal Oral Mucosa and Different Grades of Oral Squamous Cell Carcinoma: A Comparative Study.Journal of clinical and diagnostic research : JCDR · 2015Article
- Behavior of the P1.HTR mastocytoma cell line implanted in the chorioallantoic membrane of chick embryos.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Myeloid cells: Prime drivers of tumor progression.Oncoimmunology · 2012Article
- Mast cells and angiogenesis in malignant and premalignant oral lesions: An immunohistochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
- A Correlation of Serum Histamine and Mast Cell Count with the Established Prognosticators in Oral Cancer.Journal of microscopy and ultrastructureArticle
- Mast cells and oral pathologies: A Review.Journal of natural science, biology, and medicineReview
- To evaluate the role of mast cells on angiogenesis in various grades of oral squamous cell carcinoma: A histochemical study.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveAngiogenesis or neovascularization has long been known to aid in progression and metastasis of malignant tumors. Tumor angiogenesis is a complex event mediated by angiogenic factors released from cancer cells and or by host immune cells. Mast cells may induce tumor progression and potentiate metastasis by stimulating angiogenesis. The purpose of the present study was to validate topographic distribution of micro vessel density (MVD) and mast cell density (MCD) and help to elucidate the possible role of mast cells in tumor angiogenesis and correlating this with advanced disease parameters. . STUDY
designMVD and MCD were investigated in tumor specimens from 30 patients diagnosed with different histologic grades of oral squamous cell carcinoma (OSCC). Intratumor vessels were stained with collagen Type IV antibody and mast cells with Toluidine blue before being measured by light microscopy.
resultsThere was a significant correlation between MVD and disease progression and number of blood vessels increased from well to poorly differentiated OSCC where as MCD decreased.
conclusionsThese findings suggest that angiogenesis indeed occur in OSCC and might be used as an index to inflect the aggression of the disease however mast cells make up only a part of complex process of angiogenesis along with other factors secreted by tumor.
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Registered trials
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