ArticleInternational journal of obesity (2005)2012
The effect of obesity on adverse outcomes and metabolism in pediatric burn patients.
Article in International journal of obesity (2005), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Influence of obesity on clinical outcomes in hospitalized children: a systematic review.JAMA pediatrics · 2013Pooled it
- Article
- Multiplexed Human Gene Expression Analysis Reveals a Central Role of the TLR/mTOR/PPARγ and NFkB Axes in Burn and Inhalation Injury-Induced Changes in Systemic Immunometabolism and Long-Term Patient Outcomes.International journal of molecular sciences · 2022Article
- Association between body mass index and severe infection in older adults with microscopic polyangiitis: a retrospective cohort in Japan.BMC geriatrics · 2021Article
- The pathogenesis and diagnosis of sepsis post burn injury.Burns & trauma · 2021Review
- Impact of Chest Trauma and Overweight on Mortality and Outcome in Severely Injured Patients.Journal of clinical medicine · 2020Article
- Outcomes and Resource Use Among Overweight and Obese Children With Sepsis in the Pediatric Intensive Care Unit.Journal of intensive care medicine · 2020Article
- Article
- The Association of Nutrition Status Expressed as Body Mass Index z Score With Outcomes in Children With Severe Sepsis: A Secondary Analysis From the Sepsis Prevalence, Outcomes, and Therapies (SPROUT) Study.Critical care medicine · 2018Article
- Hepatic steatosis associated with decreased β-oxidation and mitochondrial function contributes to cell damage in obese mice after thermal injury.Cell death & disease · 2018Article
- Impact of Obesity during Pediatric Acute and Critical Illness.Journal of pediatric intensive care · 2015Review
- Intestine immune homeostasis after alcohol and burn injury.Shock (Augusta, Ga.) · 2015Review
- Impact of the body mass on complications and outcome in multiple trauma patients: what does the weight weigh?Mediators of inflammation · 2013Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
hypothesisObesity influences metabolism and increases the incidence of clinical complications and worsens outcomes in pediatric burn patients.
designRetrospective, single-center study. SUBJECTS: In all, 592 severely burned pediatric patients who had burns covering more than 30% of the total body surface area and who were treated between 2001 and 2008 were enrolled in this study. Patients were divided into ≥85th percentile (n=277) and normal (n=315) weight groups based on body mass index (BMI) percentiles.
resultsPatients stratified below (normal) and ≥85th percentile had similar age, gender distribution and total burn size. No significant differences were detected in the incidence of sepsis (11% for obese vs 10% for normal), the incidence of multiple organ failure (MOF) (21% for obese and 16% for normal) or mortality (11% for obese vs 8% for normal). Compared with the normal group, the ≥85th percentile group had low levels of constitutive proteins (α2macroglobulin and Apolipoprotein A1) (P<0.05 for both) as well as high levels of triglycerides and the acute-phase protein, C-reactive protein (P<0.05 for both) up to 60 days after injury. Patients ≥85th percentile showed a significant higher loss of bone mineral density and lipolysis compared with normal individuals. Stepwise logistic regression analysis revealed that BMI had a positive predictive value towards the maximum DENVER2 score, an index of organ failure (P<0.001).
conclusionsBMI≥85th percentile altered the post-burn acute phase and catabolic response but did not increase the incidence of sepsis, MOF or mortality in pediatric burn patients. Our results suggest that impaired metabolism and an altered inflammatory response already exists in patients starting at the 85th percentile BMI.
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Registered trials
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