ReviewMolecules (Basel, Switzerland)2011
Pyrene: a probe to study protein conformation and conformational changes.
Review in Molecules (Basel, Switzerland), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
48 citing papers in PubMed, 273 citations in OpenAlex.
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- 1,6-Diazapyrene: A Novel, Well-Defined, Small-Size Prototype System for Nitrogen-Containing PAHs.The journal of physical chemistry. A · 2025Article
- Crossing the Solubility Rubicon: 15-Crown-5 Facilitates the Preparation of Water-Soluble Sulfo-NHS Esters in Organic Solvents.Bioconjugate chemistry · 2024Article
- Physicochemical mechanisms of aggregation and fibril formation of α-synuclein and apolipoprotein A-I.Biophysics and physicobiology · 2024Article
- Layer-by-layer assembled film can serve as an enhanced reaction environment for Diels-Alder reaction.Frontiers in chemistry · 2024Article
- Spectroscopic and Biological Properties of the 3-Imino-1,8-naphthalimide Derivatives as Fluorophores for Cellular Imaging.Molecules (Basel, Switzerland) · 2023Article
- Article
- Gemini surfactant-like peptide-based nanocages with β-sheet-enhanced stability and encapsulation efficiency of hydrophobic anticancer drugs.RSC advances · 2023Article
- Facile Obtainment of Fluorescent PEG Hydrogels Bearing Pyrene Groups by Frontal Polymerization.Polymers · 2023Article
- Phenanthridine-pyrene conjugates as fluorescent probes for DNA/RNA and an inactive mutant of dipeptidyl peptidase enzyme.Beilstein journal of organic chemistry · 2023Article
- Multifunctional Nanoparticles as High-Efficient Targeted Hypericin System for Theranostic Melanoma.Polymers · 2022Article
- Recent Advances in Excimer-Based Fluorescence Probes for Biological Applications.Molecules (Basel, Switzerland) · 2022Review
- Simple and Rapid Endotoxin Recognition Using a Dipicolylamine-Modified Fluorescent Probe with Picomolar-Order Sensitivity.ACS omega · 2022Article
- Bioengineering a glucose oxidase nanosensor for near-infrared continuous glucose monitoring.Nanoscale advances · 2022Article
- Phase Separation of Aqueous Poly(diisopropylaminoethyl methacrylate) upon Heating.Langmuir : the ACS journal of surfaces and colloids · 2022Article
- BN-Substitution in Dithienylpyrenes Prevents Excimer Formation in Solution and in the Solid State.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022Article
- Highly Fluorescent Dyes Containing Conformationally Restrained Pyrazolylpyrene (Pyrazoolympicene) Chromophore.Molecules (Basel, Switzerland) · 2022Article
- Terpenoid Hydrazones as Biomembrane Penetration Enhancers: FT-IR Spectroscopy and Fluorescence Probe Studies.Molecules (Basel, Switzerland) · 2021Article
- Gated Photoreactivity of Pyrene Copolymers in Multiresponsive Cross-Linked starPEG-Hydrogels.ACS polymers Au · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The review focuses on the unique spectral features of pyrene that can be utilized to investigate protein structure and conformation. Pyrene is a fluorescent probe that can be attached covalently to protein side chains, such as sulfhydryl groups. The spectral features of pyrene are exquisitely sensitive to the microenvironment of the probe: it exhibits an ensemble of monomer fluorescence emission peaks that report on the polarity of the probe microenvironment, and an additional band at longer wavelengths, the appearance of which reflects the presence of another pyrene molecule in spatial proximity (~10 Å). Its high extinction coefficient allows us to study labeled proteins in solution at physiologically relevant concentrations. The environmentally- and spatially-sensitive features of pyrene allow monitoring protein conformation, conformational changes, protein folding and unfolding, protein-protein, protein-lipid and protein-membrane interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.