ArticleAntimicrobial agents and chemotherapy2012
Aerosolized gentamicin reduces the burden of tuberculosis in a murine model.
Article in Antimicrobial agents and chemotherapy, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Targeted delivery of antitubercular drugs using glucan lipid particles.Microbiology spectrum · 2025Article
- Studies of the Specific Activity of Aerosolized Isoniazid against Tuberculosis in a Mouse Model.Antibiotics (Basel, Switzerland) · 2022Article
- Article
- DosS Is required for the complete virulence of mycobacterium tuberculosis in mice with classical granulomatous lesions.American journal of respiratory cell and molecular biology · 2015Article
- Potent rifamycin-sparing regimen cures guinea pig tuberculosis as rapidly as the standard regimen.Antimicrobial agents and chemotherapy · 2013Article
- Rifapentine is not more active than rifampin against chronic tuberculosis in guinea pigs.Antimicrobial agents and chemotherapy · 2012Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
Tuberculosis (TB) is a major infectious disease problem: 1.7 million people annually die due to TB. Emergence of drug-resistant Mycobacterium tuberculosis and the lack of new antibiotics have exacerbated the situation. There is an urgent need to develop or repurpose drugs against TB. We evaluated inhaled gentamicin as direct respiratory system-targeted therapy in a murine model of TB. Aerosolized-gentamicin-treated mice showed significantly reduced lung M. tuberculosis loads and fewer granulomas relative to untreated controls. These results suggest that direct delivery of antibiotics to the respiratory system may provide therapeutic benefit to conventional treatment regimes for treatment of pulmonary TB.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.