ArticleJournal of molecular histology2012
The effect of monosodium glutamate on the cerebellar cortex of male albino rats and the protective role of vitamin C (histological and immunohistochemical study).
Article in Journal of molecular histology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 107 citations in OpenAlex.
- The Relationship between Post-Traumatic Stress Disorder Due to Brain Injury and Glutamate Intake: A Systematic Review.Nutrients · 2024Pooled it
- Neuroprotective effects of hydroxytyrosol against monosodium glutamate-induced hippocampal and cerebellar injury in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Influence of Monosodium Glutamate on Astroglia of Rat Habenula.Biomolecules · 2025Article
- Evaluation of the effects of monosodium glutamate on the development of the cerebellum in chicken embryos.Journal of molecular histology · 2025Article
- Treadmill training protects valproic acid-induced autistic features via cerebellar AMPK/PPAR-γ dependent pathway and improves mitochondrial activity in mice.Scientific reports · 2025Article
- Efficacy of Plasmalogens on Monosodium Glutamate-Induced Neurotoxicity in Male Rats Through NF-Oxidative medicine and cellular longevity · 2025Article
- Neuroprotective effect of silymarin-loaded nanoliposomes against monosodium glutamate-induced cerebellar motor deficit and Purkinje cell damage in experimental rats via PI3K/AKT pathway activation.Frontiers in molecular biosciences · 2025Article
- Monosodium Glutamate Treatment Elevates the Immunoreactivity of GFAP and S100β in Caudate Nucleus of the Striatum in Rats.Biomedicines · 2024Article
- The Role of Vitamin C on ATPases Activities in Monosodium Glutamate-Induced Oxidative Stress in Rat Striatum and Cerebellum.Neurotoxicity research · 2024Article
- Review
- Targeting Glutamate Neurotoxicity through Dietary Manipulation: Potential Treatment for Migraine.Nutrients · 2023Review
- Monosodium Glutamate Effect on The Expression of ɑ7nACHR and ɑ4nACHR Subunits in The Testicular Tissue.International journal of fertility & sterility · 2023Article
- Investigation of the Effects of Monosodium Glutamate on the Embryonic Development of the Eye in Chickens.Veterinary sciences · 2023Article
- Is L-Glutamate Toxic to Neurons and Thereby Contributes to Neuronal Loss and Neurodegeneration? A Systematic Review.Brain sciences · 2022Review
- Pomegranate peel extracts effects to reduce mono sodium glutamate toxic effects on chicken embryos: Morphological studies.Saudi journal of biological sciences · 2022Article
- Impact of cisplatin administration on cerebellar cortical structure and locomotor activity of infantile and juvenile albino rats: the role of oxidative stress.Anatomical science international · 2022Article
- Therapeutic role of adipose tissue-derived stem cells versus microvesicles in a rat model of cerebellar injury.Journal of cellular and molecular medicine · 2022Article
- Secondary Cerebellar Cortex Injury in Albino Male Rats after MCAO: A Histological and Biochemical Study.Biomedicines · 2021Article
- Monosodium glutamate induces memory and hepatic dysfunctions in mice: ameliorative role of JobelynToxicological research · 2021Article
- Synergistic Anti-inflammatory and Neuroprotective Effects ofFrontiers in cell and developmental biology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Monosodium glutamate (MSG) is a natural constituent of many foods and was reported to have neurotoxic effects. The aim of this study was to investigate the possible toxic effect of MSG on histological and glial fibrillary acidic protein (GFAP) immunohistochemical features of cerebellar cortex of albino rats and to evaluate the possible protective role of vitamin C against this effect. Thirty rats were divided into 3 equal groups. Group I, control; Group II, treated with 3 g/kg/day of MSG and Group III, received 100 mg/kg/day of vitamin C simultaneously with MSG. After 14 days, cerebellar tissues were obtained and processed to prepare sections stained with H&E, toluidine blue. The GFAP was detected immunohistochemically. Histological examination of group II showed degenerative changes as pyknotic Purkinje and granule cells with areas of degeneration surrounded by inflammatory cells in granular layer. However, group III showed more preserved histological structure of cerebellar cortex. Statistical analysis of area percent of the GFAP immunoreaction among studied groups showed significant increase in group III when compared with group I and group II. However, a non significant increase was detected in group II when compared with group I. In conclusion, MSG has neurotoxic effect leading to degenerative changes in neurons and astrocytes in cerebellar cortex of albino rats and vitamin C supplementation could protect from these changes. Getting more attention to the constituents of food products is recommended and vitamin C could be advised to protect people from food oxidants additives.
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