ArticleOdontology2013
Symptomatic and asymptomatic apical periodontitis associated with red complex bacteria: clinical and microbiological evaluation.
Article in Odontology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Association between endodontic symptoms and root canal microbiota: a systematic review and meta-analysis of bacteroidetes, spirochaetes and fusobacteriales.Clinical oral investigations · 2024Pooled it
- Ultrasonographic measurement of masseter muscle thickness and elasticity in patients with symptomatic apical periodontitis.Clinical oral investigations · 2026Article
- Do Laser-Activated Irrigation Protocols Improve Endodontic Success? A Prospective Clinical Comparison of 1-Year Periapical Healing with Sonic, Ultrasonic, Manual Dynamic and Conventional Techniques.Diagnostics (Basel, Switzerland) · 2026Article
- Review
- Accuracy of Gingival Crevicular Fluid Biomarkers of MMP8, TIMP1, RANK, RANKL, and OPG in Differentiating Symptomatic and Asymptomatic Apical Periodontitis.Diagnostics (Basel, Switzerland) · 2024Article
- Bacterial Periodontitis in Horses: An Epidemiological Study in Southern Italy.Animals : an open access journal from MDPI · 2023Article
- Microbial identification from traumatized immature permanent teeth with periapical lesions using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.BMC oral health · 2022Article
- Protective Actions in Apical Periodontitis: The Regenerative Bioactivities Led by Mesenchymal Stem Cells.Biomolecules · 2022Review
- Lipopolysaccharide fromInternational journal of molecular sciences · 2022Article
- Targeting hepatocyte growth factor in epithelial-stromal interactions in an in vitro experimental model of human periodontitis.Odontology · 2021Article
- Next-Generation Sequencing Analysis of Root Canal Microbiota Associated with a Severe Endodontic-Periodontal Lesion.Diagnostics (Basel, Switzerland) · 2021Article
- Systemic and Extraradicular Bacterial Translocation in Apical Periodontitis.Frontiers in cellular and infection microbiology · 2021Article
- Macrophages skew towards M1 profile through reduced CD163 expression in symptomatic apical periodontitis.Clinical oral investigations · 2020Article
- Expression of Toll-like receptors 2 and 4 and its association with matrix metalloproteinases in symptomatic and asymptomatic apical periodontitis.Clinical oral investigations · 2019Article
- Bone resorptive activity in symptomatic and asymptomatic apical lesions of endodontic origin.Clinical oral investigations · 2017Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study, the association of red complex (RC) bacteria that include Treponema denticola, Tannerella forsythia and Porphyromonas gingivalis with acute, exacerbated or chronic apical periodontitis was evaluated. Seventy-one patients with periapical disease were evaluated by clinical examination and microbiological samples obtained from the root canals were analyzed by a polymerase chain reaction assay. Twenty-one (29.6%) samples were positive for RC bacteria, with T. denticola, T. forsythia and P. gingivalis being detected in 14 (19.7%), 10 (14.1%) and 6 (8.5%) samples, respectively. RC bacteria were mainly associated with acute apical periodontitis (29.2%) and phoenix abscess (63.2%), while they were only sporadically detected (7.1%) in patients with chronic apical periodontitis. Generally, RC bacteria were associated with pain and a higher frequency of intracanalar/intrasulcular pus drainage. Involvement of RC bacteria in symptomatic periapical disease should be suspected in the presence of particularly severe clinical pain and pus drainage.
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Registered trials
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