ReviewCurrent opinion in nephrology and hypertension2012
Vitamin D: roles in renal and cardiovascular protection.
Review in Current opinion in nephrology and hypertension, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 55 citations in OpenAlex.
- Efficacy of single-dose cholecalciferol in the blood pressure of patients with type 2 diabetes, hypertension and hypovitaminoses D.Scientific reports · 2020Trial
- The association of 25(OH)D with blood pressure, pulse pressure and carotid-radial pulse wave velocity in African women.PloS one · 2013Trial
- High-dose cholecalciferol reduces parathyroid hormone in patients with early chronic kidney disease: a pilot, randomized, double-blind, placebo-controlled trial.The American journal of clinical nutrition · 2012Trial
- Relationship between vitamin D status, glycaemia and nephropathy in adults with type 2 diabetes mellitus.BMC endocrine disorders · 2026Article
- Vitamin D Status, Adiposity, and Insulin Resistance among U.S. Non-Hispanic Black Women: a Complex-Survey Analysis of NHANES 2011-2018.Journal of racial and ethnic health disparities · 2026Article
- Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials.Health science reports · 2025Review
- Cognitive Function and Vitamin D Status in the Chinese Hemodialysis Patients.Computational and mathematical methods in medicine · 2022Article
- Vitamin D Effects on Bone Homeostasis and Cardiovascular System in Patients with Chronic Kidney Disease and Renal Transplant Recipients.Nutrients · 2021Review
- Association between serum vitamin D and uric acid in the eastern Chinese population: a population-based cross-sectional study.BMC endocrine disorders · 2020Observational
- Association Between Vitamin D and Hyperuricemia Among Adults in the United States.Frontiers in nutrition · 2020Article
- Novel markers of graft outcome in a cohort of kidney transplanted patients: a cohort observational study.Journal of nephrology · 2019Observational
- Oral paricalcitol: expanding therapeutic options for pediatric chronic kidney disease patients.Pediatric nephrology (Berlin, Germany) · 2017Article
- Ageing Renal Patients: We Need More Collaboration between Geriatric Services and Nephrology Departments.Healthcare (Basel, Switzerland) · 2015Review
- Vitamin D depletion aggravates hypertension and target-organ damage.Journal of the American Heart Association · 2015Article
- Oral active vitamin d treatment and mortality in maintenance hemodialysis patients.Cardiorenal medicine · 2014Article
- Survival Analysis with Electronic Health Record Data: Experiments with Chronic Kidney Disease.Statistical analysis and data mining · 2014Article
- Clinical therapeutic strategies for early stage of diabetic kidney disease.World journal of diabetes · 2014Review
- Paricalcitol downregulates myocardial renin-angiotensin and fibroblast growth factor expression and attenuates cardiac hypertrophy in uremic rats.American journal of hypertension · 2014Article
- Pediatric cardiomyopathies: causes, epidemiology, clinical course, preventive strategies and therapies.Future cardiology · 2013Review
- Vitamin D receptor signaling in renal and cardiovascular protection.Seminars in nephrology · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
purpose of reviewGreat progress has been made in recent years in understanding the expanding roles of the vitamin D endocrine system beyond calcemic regulation, including pathophysiological actions in the kidney and the cardiovascular system. The purpose of this review is to update the recent advance regarding the effects of vitamin D and its analogs on the renal and cardiovascular system. RECENT
findingsVitamin D deficiency is not only widely associated with chronic kidney disease and cardiovascular disease in humans, but may also accelerate the disease progression. Dysregulation of vitamin D metabolism caused by renal insufficiency contributes to the low vitamin D status. Preclinical and clinical studies have demonstrated impressive therapeutic outcome with low-calcemic vitamin D analogs in renal and cardiovascular disease. The mechanism underlying the renal and cardiovascular protection involves regulation of multiple signaling pathways by vitamin D including nuclear factor κB, Wnt/β-catenin and the renin-angiotensin system. SUMMARY: The renal and cardiovascular protective activity of vitamin D revealed in recent studies has profound clinical implications. Nutritional correction of vitamin D deficiency and treatment with vitamin D analogs could be therapeutic options for renal and cardiovascular problems. New vitamin D analogs with better renal and cardiovascular therapeutic efficacy are highly desired. More randomized trials are needed to address these issues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.