Evidence map›Paper›PMID 22143168›Full record

ReviewAnesthesiology2012

Dysautonomia: perioperative implications.

Hossam I Mustafa, Joshua P Fessel, John Barwise, John R Shannon, Satish R Raj, André Diedrich, Italo Biaggioni, David Robertson

Registry-linked trialOpen access · bronzeAbstract readReview
In one paragraph

Review in Anesthesiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05230641 (Cardiac Autonomic Dysfunction and Perioperative Outcomes After Neurosurgery), which is not on this map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05230641 completednot on this mapstarted 2022, after this paper: background citation

Cardiac Autonomic Dysfunction and Perioperative Outcomes After Neurosurgery

TypeobservationalSponsorNational Institute of Mental Health and Neuro Sciences, IndiaRan2022 to 2023Enrolled400ConditionsNeurosurgical PatientsArmsNo intervention
3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 51 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
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  7. Article
  8. Review
  9. Article
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  11. Review
  12. Review
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Hossam I MustafaAutonomic Dysfunction Center, Division of Clinical Pharmacology, Department of Medicine, Autonomic Rare Disease Clinical Research Consortium, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2195, USA.
Joshua P Fessel
John Barwise
John R Shannon
Satish R Raj
André Diedrich
Italo Biaggioni
David Robertson
Vanderbilt University Medical Center · US

Funding

VANDERBILT UNIVERSITY CTSA FOR PEDIATRIC RESEARCHUL1RR024975 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$45.7M
Structural genomics of norepinephrine transportersP01HL056693 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI DAVIS, STEPHEN N. · 1997 to 2016
$30.8M
Training CoreU54NS065736 · NINDS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BIAGGIONI, ITALO · 2009 to 2018
$11.6M
Dopamine-B-Hydroxylase in Human Cardiovascular ControlR01HL071784 · NHLBI · VANDERBILT UNIVERSITY · PI ROBERTSON, DAVID HERLIE · 2003 to 2012
$3.6M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) KL2KL2RR024977 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$3.0M
The Vanderbilt Institute for Clinical and Translational Research (VICTR) TL1TL1RR024978 · NCRR · VANDERBILT UNIVERSITY · PI BERNARD, GORDON RAPHAEL · 2007 to 2011
$1.3M
The Role of Epinephrine in Neurally Mediated SyncopeK23RR020783 · NCRR · VANDERBILT UNIVERSITY · PI RAJ, SATISH R · 2005 to 2009
$620k
NCRR NIH HHS K23 RR020783NCRR NIH HHS KL2 RR024977NCRR NIH HHS TL1 RR024978NCRR NIH HHS UL1 RR024975NHLBI NIH HHS P01 HL056693NHLBI NIH HHS R01 HL071784NINDS NIH HHS U54 NS065736
6 · The paper itself

Abstract

Severe autonomic failure occurs in approximately 1 in 1,000 people. Such patients are remarkable for the striking and sometimes paradoxic responses they manifest to a variety of physiologic and pharmacologic stimuli. Orthostatic hypotension is often the finding most commonly noted by physicians, but a myriad of additional and less understood findings also occur. These findings include supine hypertension, altered drug sensitivity, hyperresponsiveness of blood pressure to hypo/hyperventilation, sleep apnea, and other neurologic disturbances. In this article the authors will review the clinical pathophysiology that underlies autonomic failure, with a particular emphasis on those aspects most relevant to the care of such patients in the perioperative setting. Strategies used by clinicians in diagnosis and treatment of these patients, and the effect of these interventions on the preoperative, intraoperative, and postoperative care that these patients undergo is a crucial element in the optimized management of care in these patients.

Indexed as

Perioperative CareAirway ManagementAnesthesiaBaroreflexDrug InteractionsHumansHyperventilationHypotension, OrthostaticInfectionsPostoperative CarePrimary Dysautonomias

Identifiers

PMID22143168
PMCPMC3296831
OpenAlexW1994417386

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.