ReviewNature reviews. Clinical oncology2011
Clinical and epidemiological issues in mammographic density.
Review in Nature reviews. Clinical oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02619123 (Tailored Screening for Breast Cancer in Premenopausal Women. A Translational, Randomized Population-based Trial), which is not on this map. Cited by 50 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Tailored Screening for Breast Cancer in Premenopausal Women. A Translational, Randomized Population-based Trial
Who cites it
50 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Mammographic density, endocrine therapy and breast cancer risk: a prognostic and predictive biomarker review.The Cochrane database of systematic reviews · 2021Pooled it
- Addition of ultrasound to mammography in the case of dense breast tissue: systematic review and meta-analysis.British journal of cancer · 2018Pooled it
- Effect of preventive hormonal therapy on breast density: a systematic qualitative review.TheScientificWorldJournal · 2014Pooled it
- A meta-analysis on dose-response relationship between night shift work and the risk of breast cancer.Annals of oncology : official journal of the European Society for Medical Oncology · 2013Pooled it
- Large-scale genotyping identifies a new locus at 22q13.2 associated with female breast size.Journal of medical genetics · 2013Pooled it
- A novel automated mammographic density measure and breast cancer risk.Journal of the National Cancer Institute · 2012Pooled it
- Circulating sex hormones and volumetric breast density: A prospective study in women from the EPIC Florence cohort.International journal of cancer · 2025Article
- Education and mammographic breast density.Breast cancer research and treatment · 2025Article
- Breast cancer classification based on breast tissue structures using the Jigsaw puzzle task in self-supervised learning.Radiological physics and technology · 2025Article
- MRI-based Deep Learning Models for Preoperative Breast Volume and Density Assessment Assisting Breast Reconstruction.Aesthetic plastic surgery · 2024Article
- Disentangling the relationships of body mass index and circulating sex hormone concentrations in mammographic density using Mendelian randomization.Breast cancer research and treatment · 2024Article
- Mammographic density and exposure to air pollutants in premenopausal women: a cross-sectional study.Environmental health and preventive medicine · 2024Article
- IGFBP2 secretion by mammary adipocytes limits breast cancer invasion.Science advances · 2023Article
- Breast Dense Tissue Segmentation with Noisy Labels: A Hybrid Threshold-Based and Mask-Based Approach.Diagnostics (Basel, Switzerland) · 2022Article
- Factors Influencing Mammographic Density in Asian Women: A Retrospective Cohort Study in the Northeast Region of Peninsular Malaysia.Diagnostics (Basel, Switzerland) · 2022Article
- Quantitative breast density analysis to predict interval and node-positive cancers in pursuit of improved screening protocols: a case-control study.British journal of cancer · 2021Article
- Prediagnostic circulating metabolites in female breast cancer cases with low and high mammographic breast density.Scientific reports · 2021Article
- Mammographic Breast Density and Urbanization: Interactions with BMI, Environmental, Lifestyle, and Other Patient Factors.Diagnostics (Basel, Switzerland) · 2020Article
- External validation of a mammographic texture marker for breast cancer risk in a case-control study.Journal of medical imaging (Bellingham, Wash.) · 2020Article
- Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: a meta-analysis.Gland surgery · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High mammographic density is associated with an increased risk of breast cancer, and of all known breast cancer risk factors has the greatest attributable fraction. Mammographic density is estimated to account for 16% of all breast cancers, but can be altered by endogenous and exogenous hormonal factors, and generally declines with age. Confounding factors such as age, parity, menopausal status and BMI make the interpretation of mammographic density particularly challenging. Furthermore, none of the established means of measuring mammographic density are entirely satisfactory because they are time consuming or subjective. It is hoped that by adding information regarding mammographic density to existing models of breast cancer risk assessment, the accuracy of individual risk assessments can be improved. Although mammographic density has clearly been shown to be a powerful factor for predicting the risk of developing breast cancer, its potential role in assessing hormonal preventive regimens and helping to tailor screening algorithms cannot be fully realized until we have more-precise, simple and reproducible density measures.
Indexed as
Identifiers
22143145What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.