ArticleDevelopmental biology2012
Differential regulation of epiboly initiation and progression by zebrafish Eomesodermin A.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Early ultraviolet exposure disrupts late dorsal fin skeletal development in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- CRISPR/Cas9-Mediated Disruption ofInternational journal of molecular sciences · 2025Article
- The sclerotome is the source of the dorsal and anal fin skeleton and its expansion is required for median fin development.Development (Cambridge, England) · 2024Article
- Protein profiling of zebrafish embryos unmasks regulatory layers during early embryogenesis.Cell reports · 2024Article
- Screening of functional maternal-specific chromatin regulators in early embryonic development of zebrafish.Communications biology · 2024Article
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- Maternal Factors and Nodal Autoregulation OrchestrateFrontiers in cell and developmental biology · 2022Article
- Eomes function is conserved between zebrafish and mouse and controls left-right organiser progenitor gene expression via interlocking feedforward loops.Frontiers in cell and developmental biology · 2022Article
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- Tris(1,3-dichloro-2-propyl) Phosphate Exposure During the Early-Blastula Stage Alters the Normal Trajectory of Zebrafish Embryogenesis.Environmental science & technology · 2018Article
- Long-Range Signaling Activation and Local Inhibition Separate the Mesoderm and Endoderm Lineages.Developmental cell · 2018Article
- In Vivo Regulation of the Zebrafish Endoderm Progenitor Niche by T-Box Transcription Factors.Cell reports · 2017Article
- Article
- Type-IV antifreeze proteins are essential for epiboly and convergence in gastrulation of zebrafish embryos.International journal of biological sciences · 2014Article
- Microtubule-associated protein 9 (Map9/Asap) is required for the early steps of zebrafish development.Cell cycle (Georgetown, Tex.) · 2014Article
- Article
- 2-O-sulfotransferase regulates Wnt signaling, cell adhesion and cell cycle during zebrafish epiboly.Development (Cambridge, England) · 2012Article
- Adherens junction function and regulation during zebrafish gastrulation.Cell adhesion & migrationArticle
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
Abstract
The T-box transcription factor Eomesodermin (Eomes) has been implicated in patterning and morphogenesis in frog, fish and mouse. In zebrafish, one of the two Eomes homologs, Eomesa, has been implicated in dorsal-ventral patterning, epiboly and endoderm specification in experiments employing over-expression, dominant-negative constructs and antisense morpholino oligonucleotides. Here we report for the first time the identification and characterization of an Eomesa mutant generated by TILLING. We find that Eomesa has a strictly maternal role in the initiation of epiboly, which involves doming of the yolk cell up into the overlying blastoderm. By contrast, epiboly progression is normal, demonstrating for the first time that epiboly initiation is genetically separable from progression. The yolk cell microtubules, which are required for epiboly, are defective in maternal-zygotic eomesa mutant embryos. In addition, the deep cells of the blastoderm are more tightly packed and exhibit more bleb-like protrusions than cells in control embryos. We postulate that the doming delay may be the consequence both of overly stabilized yolk cell microtubules and defects in the adhesive properties or motility of deep cells. We also show that Eomesa is required for normal expression of the endoderm markers sox32, bon and og9x; however it is not essential for endoderm formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.