ReviewFrontiers of oral biology2012
Animal models to study host-bacteria interactions involved in periodontitis.
Review in Frontiers of oral biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
102 citing papers in PubMed, 192 citations in OpenAlex.
- IL-36γ is a pivotal inflammatory player in periodontitis-associated bone loss.Scientific reports · 2019Trial
- Influence of Genetic and Epigenetic Factors on Periodontitis Susceptibility and Treatment Outcomes.Biochemical genetics · 2026Review
- Inhibition of CD38 by 78c Enhanced NADInternational journal of molecular sciences · 2026Article
- Maxillary second molar root fusion: incidence and relationship with alveolar bone loss in ICR mice.Journal of periodontal & implant science · 2026Article
- Bone and Infections: An Osteoimmunological Interplay.International journal of molecular sciences · 2026Review
- Adjunctive Therapies in Periodontitis: Current Concepts and the Future.Journal of periodontal research · 2026Review
- Chronic periodontitis and systemic inflammation in the elderly: implications for neurodegeneration.Journal of neuroinflammation · 2026Review
- A Mouse Model for Fusobacterium nucleatum-Mediated Experimental Periodontitis.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Virulence arresting drug discovery by strategies targeting bacterial virulence: Mainly focusing on quorum-sensing interference and biofilm inhibition.Journal of pharmaceutical analysis · 2025Review
- Injectable Thermosensitive Hydrogel Containing Bakuchiol Reduces Periodontal Inflammation and Alveolar Bone Loss in a Rat Model.Journal of functional biomaterials · 2025Article
- Novel Animal Model of Enterobacteria Pathogenicity, Virulence, and Amoxicillin-Biosurfactant Synergic Using Nsombé (Rhynchophorus phoenicis Larvae).MicrobiologyOpen · 2025Article
- Establishing a Dual Murine Model to Explore the Interactions Between Diabetes and Periodontitis in Mice.International journal of molecular sciences · 2025Article
- Comparison of Micro-CT and Morphometric Outcomes in a Modified Experimental Rat Model of Periodontitis.Journal of periodontal research · 2025Article
- Sex effects on early life features of the gingival transcriptome.Frontiers in dental medicine · 2025Article
- Effectiveness of Local Use of Green Propolis-Loaded Lipid Nanoparticles as Adjuvant Therapy to Scaling and Root Planing in the Management of Periodontitis in Rats Treated with Zoledronate.International journal of molecular sciences · 2024Article
- Induced Periodontitis in Rats With Three Ligature Types: An Exploratory Study.Clinical and experimental dental research · 2024Article
- A Flagellin-Adjuvanted Trivalent Mucosal Vaccine Targeting Key Periodontopathic Bacteria.Vaccines · 2024Article
- hTERT Peptide Fragment GV1001 Prevents the Development ofInternational journal of molecular sciences · 2024Article
- Assessment of the Effect on Periodontitis of Antibiotic Therapy and Bacterial Lysate Treatment.International journal of molecular sciences · 2024Article
- The IL-33/ST2 axis is protective against acute inflammation during the course of periodontitis.Nature communications · 2024Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Animal models have distinct advantages because they can mimic cellular complexities that occur in humans in vivo and are often more accurate than in vitro studies that take place on plastic surfaces with limited numbers of cell types present. Furthermore, cause and effect relationships can be established by applying inhibitors or activators or through the use of genetically modified animals. Such gain or loss of function studies are often difficult to achieve in human clinical studies, particularly in obtaining target tissue due to important ethical considerations. Animal models in periodontal disease are particularly important at this point in the development of the scientific basis for understanding the predominant pathological processes. Periodontal disease can be broken down into discrete steps, each of which may be studied separately depending upon the animal model. These steps involve the development of a pathogenic biofilm, invasion of connective tissue by bacteria or their products, induction of a destructive host response in connective tissue and limitation of are pair process that follows tissue breakdown. Animal studies can test hypotheses related to each of these steps, and should be evaluated by their capacity to test a specific hypothesis rather than recapitulating all aspects of periodontal disease. Thus, each of the models described below can be adapted to test discrete components of the pathological process of periodontal disease, but not necessarily all of them.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.