ArticleEnvironmental health perspectives2012
Response inhibition and error monitoring during a visual go/no-go task in inuit children exposed to lead, polychlorinated biphenyls, and methylmercury.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.
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Who cites it
49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 106 citations in OpenAlex.
- Exploring the relationships between nutrition and brain health among Indigenous Peoples in North America: a systematic review.Canadian journal of public health = Revue canadienne de sante publique · 2026Pooled it
- A Systematic Review on the Influences of Neurotoxicological Xenobiotic Compounds on Inhibitory Control.Frontiers in behavioral neuroscience · 2019Pooled it
- Neurodevelopmental effects of methylmercury (MeHg): a review of epidemiological points of departure (PoDs), toxicological reference values (TRVs), and key uncertainties in human health risk assessment.Archives of toxicology · 2026Review
- Associations between prenatal exposure to a mixture of lead, mercury and polychlorinated biphenyls and executive function in Inuit adolescents.Environmental research · 2025Article
- Application of an Ecological Approach to Assessment of Nutrition in School-Aged Children-A Report from the "Biomarkers of Nutrition for Development: Knowledge Indicating Dietary Sufficiency (BOND-KIDS)" Project Working Group 3.The Journal of nutrition · 2025Review
- Effects of prenatal lead, mercury, cadmium, and arsenic exposure on children's neurodevelopment in an artisanal small-scale gold mining area in Northwestern Tanzania using a multi-chemical exposure model.PLOS global public health · 2025Article
- Metal exposure in the Greenlandic ACCEPT cohort: follow-up and comparison with other Arctic populations.International journal of circumpolar health · 2024Article
- Effects of Blood Lead Levels <10 µg/dL in School-Age Children and Adolescents: A Scoping Review.Pediatrics · 2024Article
- Pre-natal and early life lead exposure and childhood inhibitory control: an item response theory approach to improve measurement precision of inhibitory control.Environmental health : a global access science source · 2024Article
- Sources of exposure to lead in Arctic and subarctic regions: a scoping review.International journal of circumpolar health · 2023Article
- Review
- Interval timing relative to response inhibition in the differential reinforcement of low-rate responding in normally developing young adults.Scientific reports · 2023Article
- Pre- and postnatal exposure to legacy environmental contaminants and sensation seeking in Inuit adolescents from Nunavik.PLOS global public health · 2023Article
- Associations between developmental exposure to environmental contaminants and spatial navigation in late adolescence.New directions for child and adolescent development · 2022Article
- Article
- Article
- Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age: a Greenlandic cohort study.Scientific reports · 2021Article
- Time Trend of Persistent Organic Pollutants and Metals in Greenlandic Inuit during 1994-2015.International journal of environmental research and public health · 2021Article
- Inuit Country Food and Health during Pregnancy and Early Childhood in the Circumpolar North: A Scoping Review.International journal of environmental research and public health · 2021Article
- Human Health and Ocean Pollution.Annals of global health · 2020Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundLead (Pb) and polychlorinated biphenyls (PCBs) are neurotoxic contaminants that have been related to impairment in response inhibition.
objectivesIn this study we examined the neurophysiological correlates of the response inhibition deficits associated with these exposures, using event-related potentials (ERPs) in a sample of school-age Inuit children from Arctic Québec exposed through their traditional diet.
methodsIn a prospective longitudinal study, we assessed 196 children (mean age, 11.3 years) on a visual go/no-go response inhibition paradigm. Pb, PCB, and mercury (Hg) concentrations were analyzed in cord and current blood samples. Hierarchical multiple regression analyses were conducted to examine the associations of contaminant levels to go/no-go performance (mean reaction time, percent correct go, percent correct no-go) and five ERPs [N2, P3, error-related negativity, error positivity (Pe), and correct response positivity (Pc)] after control for confounding variables.
resultsCurrent blood Pb concentrations were associated with higher rates of false alarms and with decreased P3 amplitudes to go and no-go trials. Current plasma PCB-153 concentrations were associated with slower reaction times and with reduced amplitudes of the Pe and Pc response-related potentials. Hg concentrations were not related to any outcome on this task but showed significant interactions with other contaminants on certain outcomes.
conclusionsThese results suggest that Pb exposure during childhood impairs the child's ability to allocate the cognitive resources needed to correctly inhibit a prepotent response, resulting in increased impulsivity. By contrast, postnatal PCB exposure appears to affect processes associated with error monitoring, an aspect of behavioral regulation required to adequately adapt to the changing demands of the environment, which results in reduced task efficiency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.