ArticleEnvironmental health perspectives2012
Lead concentrations in relation to multiple biomarkers of cardiovascular disease: the Normative Aging Study.
Article in Environmental health perspectives, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 50 citations in OpenAlex.
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- Association between heavy metal exposure and high-sensitivity C-reactive protein in the elderly: Korea National Health and Nutrition Examination Survey (KNHANES) 2016-2017.Annals of occupational and environmental medicine · 2026Article
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- Associations between heavy metal exposure and vascular age: a large cross-sectional study.Journal of translational medicine · 2025Article
- Association between lead and circulating markers of inflammation among traffic enforcers in Metro Manila, Philippines: the MMDA traffic enforcer's health study.International archives of occupational and environmental health · 2024Article
- Involvement of Nrf2 Signaling in Lead-induced Toxicity.Current medicinal chemistry · 2024Review
- The protective effect of red cabbage on water-soluble fractions of spent crankcase oil-induced alterations in lipid function biomarkers and atherogenic indices in male Albino rats.Toxicology research · 2023Article
- Longitudinal Trends in Blood Pressure Associated with The Changes in Living Environment Caused by the Great East Japan Earthquake: The Fukushima Health Management Survey.International journal of environmental research and public health · 2023Article
- Lead exposure is non-linearly associated with subclinical myocardial injury in the general population without cardiovascular disease.Frontiers in public health · 2022Article
- Blood Lead and High-Density Lipoprotein Concentrations in Relation to Human Blood Pressure: A Cross Sectional Study.Frontiers in nutrition · 2022Article
- Associations between acute and long-term exposure to PM2.5 components and temperature with QT interval length in the VA Normative Aging Study.European journal of preventive cardiology · 2021Article
- Associations between PMEnvironmental research · 2021Article
- Environmental heavy metals and cardiovascular diseases: Status and future direction.Chronic diseases and translational medicine · 2020Review
- Article
- Association of lead exposure with cardiovascular risk factors and diseases in Chinese adults.Environmental science and pollution research international · 2017Article
- Associations between lead concentrations and cardiovascular risk factors in U.S. adolescents.Scientific reports · 2017Article
- Association between dietary lead intake and 10-year mortality among Chinese adults.Environmental science and pollution research international · 2017Article
- Association Between Particulate Air Pollution and QT Interval Duration in an Elderly Cohort.Epidemiology (Cambridge, Mass.) · 2016Article
- The Microbiome and Sustainable Healthcare.Healthcare (Basel, Switzerland) · 2015Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundLead exposure has been associated with cardiovascular disease (CVD) in animal and human studies. However, the mechanisms of action have not been fully elucidated. We therefore examined the relationship between lead and multiple biomarkers of CVD.
methodsParticipants were older men from the Normative Aging Study without preexisting coronary heart disease, diabetes, or active infection at baseline (n = 426). Serum biomarkers included lipid profile [total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides] and inflammatory markers [C-reactive protein, intercellular adhesion molecule-1, interleukin-6, and tumor necrosis factor receptor-2 (TNF-R2)]. We measured lead in blood and in bone by K-shell X-ray fluorescence. In this sample, 194 men (44.3%) had two or more repeated measures, resulting in 636 observations for analysis. We conducted analyses using mixed effects models with random subject intercepts.
resultsLead levels were associated with several CVD biomarkers, including levels of TNF-R2 and lipid markers. Specifically, in multivariable models, a 50% increase in blood lead level was associated with 26% increased odds of high TNF-R2 levels (> 5.52 ng/mL; odds ratio = 1.26; 95% confidence interval: 1.09, 1.45). There were positive associations of blood lead level with total cholesterol and HDL levels, and these associations were more evident when modeled as continuous outcomes than when categorized using clinically relevant cut points. In addition, longitudinal analyses indicated a significant increase in TNF-R2 levels over time to be associated with high blood lead level at the preceding visit.
conclusionsBlood lead level may be related with CVD in healthy older men through its association with TNF-R2 levels. In addition, the magnitude of the association of blood lead level with TNF-R2 level increased with age in the study population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.