ArticlePloS one2011
The multi-level action of fatty acids on adiponectin production by fat cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 44 citations in OpenAlex.
- Response of Primary Human Adipocytes to Fatty Acid Treatment.Journal of cellular and molecular medicine · 2025Article
- Adiponectin Resistance in Obesity: Adiponectin Leptin/Insulin Interaction.Advances in experimental medicine and biology · 2024Review
- The negative association of lower body fat mass with cardiometabolic disease risk factors is partially mediated by adiponectin.Endocrine connections · 2022Article
- The PPARPPAR research · 2020Review
- Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes.Biochimica et biophysica acta. Molecular basis of disease · 2017Article
- Reduced adiponectin expression after high-fat diet is associated with selective up-regulation of ALDH1A1 and further retinoic acid receptor signaling in adipose tissue.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2017Article
- Even- and odd-chain saturated fatty acids in serum phospholipids are differentially associated with adipokines.PloS one · 2017Article
- Article
- Fasting and postprandial regulation of the intracellular localization of adiponectin and of adipokines secretion by dietary fat in rats.Nutrition & diabetes · 2015Article
- Maternal obesity and metabolic risk to the offspring: why lifestyle interventions may have not achieved the desired outcomes.International journal of obesity (2005) · 2015Review
- Dysregulation of Autonomic Nervous System in Chagas' Heart Disease Is Associated with Altered Adipocytokines Levels.PloS one · 2015Article
- Sortilin and lipoprotein metabolism: making sense out of complexity.Current opinion in lipidology · 2014Review
- Patterns of adiponectin expression in term pregnancy: impact of obesity.The Journal of clinical endocrinology and metabolism · 2014Article
- Is the adiponectin-AMPK-mitochondrial axis involved in progression of nonalcoholic fatty liver disease?Hepatology (Baltimore, Md.) · 2014Article
- Article
- Decreased serum level of miR-146a as sign of chronic inflammation in type 2 diabetic patients.PloS one · 2014Article
- Adiponectin in inflammatory and immune-mediated diseases.Cytokine · 2013Review
- Diet, obesity, and cancer progression: are adipocytes the link?Lipid insights · 2013Review
- Have guidelines addressing physical activity been established in nonalcoholic fatty liver disease?World journal of gastroenterology · 2012Review
- Hepatic sortilin regulates both apolipoprotein B secretion and LDL catabolism.The Journal of clinical investigation · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Current epidemics of diabetes mellitus is largely caused by wide spread obesity. The best-established connection between obesity and insulin resistance is the elevated and/or dysregulated levels of circulating free fatty acids that cause and aggravate insulin resistance, type 2 diabetes, cardiovascular disease and other hazardous metabolic conditions. Here, we investigated the effect of a major dietary saturated fatty acid, palmitate, on the insulin-sensitizing adipokine adiponectin produced by cultured adipocytes. We have found that palmitate rapidly inhibits transcription of the adiponectin gene and the release of adiponectin from adipocytes. Adiponectin gene expression is controlled primarily by PPARγ and C/EBPα. Using mouse embryonic fibroblasts from C/EBPα-null mice, we have determined that the latter transcription factor may not solely mediate the inhibitory effect of palmitate on adiponectin transcription leaving PPARγ as a likely target of palmitate. In agreement with this model, palmitate increases phosphorylation of PPARγ on Ser273, and substitution of PPARγ for the unphosphorylated mutant Ser273Ala blocks the effect of palmitate on adiponectin transcription. The inhibitory effect of palmitate on adiponectin gene expression requires its intracellular metabolism via the acyl-CoA synthetase 1-mediated pathway. In addition, we found that palmitate stimulates degradation of intracellular adiponectin by lysosomes, and the lysosomal inhibitor, chloroquine, suppressed the effect of palmitate on adiponectin release from adipocytes. We present evidence suggesting that the intracellular sorting receptor, sortilin, plays an important role in targeting of adiponectin to lysosomes. Thus, palmitate not only decreases adiponectin expression at the level of transcription but may also stimulate lysosomal degradation of newly synthesized adiponectin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.