ArticlePloS one2011
Risk factors for chronic cerebrospinal venous insufficiency (CCSVI) in a large cohort of volunteers.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 45 citations in OpenAlex.
- Trial
- A Review of the Association Between Dietary Intake and Brain Iron Levels in Older Adults: Preliminary Findings and Future Directions.Nutrients · 2024Review
- Lacunes are associated with late-stage multiple sclerosis comorbidities.Frontiers in neurology · 2023Article
- Susceptibility networks reveal independent patterns of brain iron abnormalities in multiple sclerosis.NeuroImage · 2022Article
- Self-Reported Diet and Health Outcomes of Participants of the CCSVI-Tracking Survey Study.Nutrients · 2021Article
- Use of patient-reported data in determining factors contributing to internal jugular vein stenosis outcomes.Annals of translational medicine · 2020Article
- Lower total cerebral arterial flow contributes to cognitive performance in multiple sclerosis patients.Multiple sclerosis (Houndmills, Basingstoke, England) · 2020Article
- Dietary and lifestyle factors in multiple sclerosis progression: results from a 5-year longitudinal MRI study.Journal of neurology · 2019Article
- Understanding jugular venous outflow disturbance.CNS neuroscience & therapeutics · 2018Review
- Interdependence of oxysterols with cholesterol profiles in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2017Observational
- Impaired Neurovisceral Integration of Cardiovascular Modulation Contributes to Multiple Sclerosis Morbidities.Molecular neurobiology · 2017Review
- Genetic, Epigenetic, and Environmental Factors Influencing Neurovisceral Integration of Cardiovascular Modulation: Focus on Multiple Sclerosis.Neuromolecular medicine · 2016Review
- Article
- Increased contrast enhancing lesion activity in relapsing-remitting multiple sclerosis migraine patients.NeuroImage. Clinical · 2015Article
- Prevalence of radiologically isolated syndrome and white matter signal abnormalities in healthy relatives of patients with multiple sclerosis.AJNR. American journal of neuroradiology · 2014Article
- Potential involvement of the extracranial venous system in central nervous system disorders and aging.BMC medicine · 2013Review
- Is there a link between the extracranial venous system and central nervous system pathology?BMC medicine · 2013Article
- No evidence for impairment of venous hemodynamics in children or young adults with pediatric-onset multiple sclerosis.AJNR. American journal of neuroradiology · 2013Article
- Internal jugular venous abnormalities in transient monocular blindness.BMC neurology · 2013Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe role of intra- and extra-cranial venous system impairment in the pathogenesis of various vascular, inflammatory and neurodegenerative neurological disorders, as well as in aging, has not been studied in detail. Nor have risk factors been determined for increased susceptibility of venous pathology in the intra-cranial and extra-cranial veins. The aim of this study was to investigate the association between presence of a newly proposed vascular condition called chronic cerebrospinal venous insufficiency (CCSVI) and environmental factors in a large volunteer control group without known central nervous system pathology. METHODS AND
findingsThe data were collected in a prospective study from 252 subjects who were screened for medical history as part of the entry criteria and participated in the case-control study of CCSVI prevalence in multiple sclerosis (MS) patients, and then were analyzed post-hoc. All participants underwent physical and Doppler sonography examinations, and were assessed with a structured environmental questionnaire. Fullfilment of ≥ 2 positive venous hemodynamic (VH) criteria on Doppler sonography was considered indicative of CCSVI diagnosis. Risk and protective factors associated with CCSVI were analyzed using logistic regression analysis. Seventy (27.8%) subjects presented with CCSVI diagnosis and 153 (60.7%) presented with one or more VH criteria. The presence of heart disease (p = .001), especially heart murmurs (p = .007), a history of infectious mononucleosis (p = .002), and irritable bowel syndrome (p = .005) were associated with more frequent CCSVI diagnosis. Current or previous smoking (p = .029) showed a trend for association with more frequent CCSVI diagnosis, while use of dietary supplements (p = .018) showed a trend for association with less frequent CCSVI diagnosis.
conclusionsRisk factors for CCSVI differ from established risk factors for peripheral venous diseases. Vascular, infectious and inflammatory factors were associated with higher CCSVI frequency.
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