ArticlePloS one2011
Quantitative high-resolution genomic analysis of single cancer cells.
Article in PloS one, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- Heterogeneity of estrogen receptor expression in circulating tumor cells from metastatic breast cancer patients.PloS one · 2013Trial
- Mouse-to-mouse variation in maturation heterogeneity of smooth muscle cells.Lab on a chip · 2018Article
- Profiling protein expression in circulating tumour cells using microfluidic western blotting.Nature communications · 2017Observational
- Analysis of circulating tumor cells from lung cancer patients with multiple biomarkers using high-performance size-based microfluidic chip.Oncotarget · 2017Article
- Comparison of microbial DNA enrichment tools for metagenomic whole genome sequencing.Journal of microbiological methods · 2016Article
- Assessment of whole genome amplification for sequence capture and massively parallel sequencing.PloS one · 2014Article
- Tumor metastasis: moving new biological insights into the clinic.Nature medicine · 2013Review
- Breast cancer as a systemic disease: a view of metastasis.Journal of internal medicine · 2013Review
- Tumor cell dissemination: emerging biological insights from animal models and cancer patients.Cancer cell · 2013Review
- Circulating tumor cells as therapy-related biomarkers in cancer patients.Cancer immunology, immunotherapy : CII · 2013Review
- Semiautomated isolation and molecular characterisation of single or highly purified tumour cells from CellSearch enriched blood samples using dielectrophoretic cell sorting.British journal of cancer · 2013Article
- High-throughput sequencing for biology and medicine.Molecular systems biology · 2013Review
- Highly selective biomechanical separation of cancer cells from leukocytes using microfluidic ratchets and hydrodynamic concentrator.Biomicrofluidics · 2013Article
- SNP microarray analyses reveal copy number alterations and progressive genome reorganization during tumor development in SVT/t driven mice breast cancer.BMC cancer · 2012Article
- Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During cancer progression, specific genomic aberrations arise that can determine the scope of the disease and can be used as predictive or prognostic markers. The detection of specific gene amplifications or deletions in single blood-borne or disseminated tumour cells that may give rise to the development of metastases is of great clinical interest but technically challenging. In this study, we present a method for quantitative high-resolution genomic analysis of single cells. Cells were isolated under permanent microscopic control followed by high-fidelity whole genome amplification and subsequent analyses by fine tiling array-CGH and qPCR. The assay was applied to single breast cancer cells to analyze the chromosomal region centred by the therapeutical relevant EGFR gene. This method allows precise quantitative analysis of copy number variations in single cell diagnostics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.