ArticleEukaryotic cell2012
SWP5, a spore wall protein, interacts with polar tube proteins in the parasitic microsporidian Nosema bombycis.
Article in Eukaryotic cell, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 101 citations in OpenAlex.
- Article
- Expression and Functional Characterisation of EhSWP26 in Ecytonucleospora hepatopenaei: Insights From RNA Interference and Subcellular Localisation Analyses.Journal of fish diseases · 2026Article
- NcSWP8, a New Spore Wall Protein, Interacts with Polar Tube Proteins in the Parasitic MicrosporidiaMicroorganisms · 2025Article
- NcPTP2, a polar tube protein, interacts with spore wall protein in the parasitic microsporidian Nosema ceranae.Molecular biology reports · 2024Article
- Transcriptomic changes in the microsporidia proliferation and host responses in congenitally infected embryos and larvae.BMC genomics · 2024Article
- The microsporidian polar tube: origin, structure, composition, function, and application.Parasites & vectors · 2023Review
- Germination of Microsporidian Spores: The Known and Unknown.Journal of fungi (Basel, Switzerland) · 2023Review
- Identification and localization of polar tube proteins in the extruded polar tube of the microsporidian Anncaliia algerae.Scientific reports · 2023Article
- Physicochemical properties, molecular structure, antioxidant activity, and biological function of extracellular melanin fromJournal of Zhejiang University. Science. B · 2022Article
- Proteomic Analysis of Spore Surface Proteins and Characteristics of a Novel Spore Wall Protein and Biomarker, EhSWP3, from the Shrimp MicrosporidiumMicroorganisms · 2022Article
- Identification and subcellular localization analysis of membrane protein Ycf 1 in the microsporidianPeerJ · 2022Article
- Identification and Characterization of Three Spore Wall Proteins ofFrontiers in cellular and infection microbiology · 2022Article
- In-depth investigation of microRNA-mediated cross-kingdom regulation between Asian honey bee and microsporidian.Frontiers in microbiology · 2022Article
- The Function and Structure of the Microsporidia Polar Tube.Experientia supplementum (2012) · 2022Article
- Identification and characterization a novel polar tube protein (NbPTP6) from the microsporidian Nosema bombycis.Parasites & vectors · 2020Article
- Invasion of Host Cells by Microsporidia.Frontiers in microbiology · 2020Review
- Article
- Identification, characterization and heparin binding capacity of a spore-wall, virulence protein from the shrimp microsporidian, Enterocytozoon hepatopenaei (EHP).Parasites & vectors · 2018Article
- A Novel Spore Wall Protein from Antonospora locustae (Microsporidia: Nosematidae) Contributes to Sporulation.The Journal of eukaryotic microbiology · 2017Article
- Microsporidia: Obligate Intracellular Pathogens Within the Fungal Kingdom.Microbiology spectrum · 2017Review
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microsporidia are a group of eukaryotic intracellular parasites that infect almost all vertebrates and invertebrates. The microsporidian invasion process involves the extrusion of a unique polar tube into host cells. Both the spore wall and the polar tube play an important role in microsporidian pathogenesis. So far, five spore wall proteins (SWP1, SWP2, Enp1, Enp2, and EcCDA) from Encephalitozoon intestinalis and Encephalitozoon cuniculi and five spore wall proteins (SWP32, SWP30, SWP26, SWP25, and NbSWP5) from the silkworm pathogen Nosema bombycis have been identified. Here we report the identification and characterization of a spore wall protein (SWP5) with a molecular mass of 20.3 kDa in N. bombycis. This protein has low sequence similarity to other eukaryotic proteins. Immunolocalization analysis showed SWP5 localized to the exospore and the region of the polar tube in mature spores. Immunoprecipitation, mass spectrometry, and immunofluorescence analyses revealed that SWP5 interacts with the polar tube proteins PTP2 and PTP3. Anti-SWP5 serum pretreatment of mature spores significantly decreased their polar tube extrusion rate. Taken together, our results show that SWP5 is a spore wall protein localized to the spore wall and that it interacts with the polar tube, may play an important role in supporting the structural integrity of the spore wall, and potentially modulates the course of infection of N. bombycis.
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