ArticleNeurorehabilitation and neural repair2012
Quadriceps muscle weakness, activation deficits, and fatigue with Parkinson disease.
Article in Neurorehabilitation and neural repair, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.
- Pooled it
- Trial
- Exercise and medication effects on persons with Parkinson disease across the domains of disability: a randomized clinical trial.Journal of neurologic physical therapy : JNPT · 2015Trial
- A two-year randomized controlled trial of progressive resistance exercise for Parkinson's disease.Movement disorders : official journal of the Movement Disorder Society · 2013Trial
- Exercise for people in early- or mid-stage Parkinson disease: a 16-month randomized controlled trial.Physical therapy · 2012Trial
- LaminA/C-dependent cellular senescence signaling promotes skeletal muscle atrophy and abnormalities in Parkinson's disease.Cell death & disease · 2026Article
- Sex Differences in Motor Unit Behavior in Patients With Parkinson's Disease.The European journal of neuroscience · 2025Article
- Review
- Shear wave elastography characteristics of the gastrocnemius muscle in postural instability gait disorder vs tremor dominant Parkinson's disease patients.Acta neurologica Belgica · 2024Article
- Parkinson's disease is associated with low striated esophagus contractility potentially contributing to the development of dysphagia.Neurogastroenterology and motility · 2024Article
- Defecatory disorders are a common cause of chronic constipation in Parkinson disease.Neurogastroenterology and motility · 2024Article
- Characterization of the vastus lateralis torque-length, and knee extensors torque-velocity and power-velocity relationships in people with Parkinson's disease.Frontiers in sports and active living · 2024Article
- Impaired skeletal muscle health in Parkinsonian syndromes: clinical implications, mechanisms and potential treatments.Journal of cachexia, sarcopenia and muscle · 2023Review
- Muscle strength and spatiotemporal gait parameters in people with Parkinson´s disease. A pilot study.Revista de neurologia · 2023Article
- Lower Limb Muscle Fatigue Alters Spatiotemporal Gait Parameters and Turning Difficulty Characteristics in Parkinson's Disease.Annals of rehabilitation medicine · 2023Article
- Physiological and clinical responses to cycling 7850 km over 85 days in a physically active middle-aged man with idiopathic Parkinson's disease.Physiological reports · 2023Article
- The Role of Muscle Strength in the Sit-to-Stand Task in Parkinson's Disease.Parkinson's disease · 2023Article
- Comparison of the mass and amount of intramuscular non-contractile tissue of the trunk and lower extremity muscles between patients with Parkinson's disease and community-dwelling older adults.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Comparison of erector spinae fatigability between female patients with Parkinson's disease and healthy individuals: a cross sectional pilot study.BMC neurology · 2022Article
- Mitigating Gait Decline in a Woman With Parkinson's Disease: A Case Report.Journal of medical cases · 2022Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPeople with Parkinson disease (PD) typically have complaints of weakness. The mechanisms underlying this deficit have not been well established, although many factors may contribute.
objectiveThis investigation aimed to characterize quadriceps muscle weakness and activation failure in people with PD and explore whether these deficits were related to disease severity. The authors further sought to examine quadriceps muscle fatigability.
methodsThis was a cross-sectional comparison of 17 people with mild-severe PD and 17 healthy adults matched by age, sex, and body mass index (BMI). The Unified Parkinson's Disease Rating Scale motor score (UPDRS motor) ranged from 9.5 to 61.0. Participants were divided into those with low-PD motor signs (UPDRS motor < 31.7) and high-PD motor signs (UPDRS motor ≥ 31.7). Measures of quadriceps performance included isometric torque, central activation using doublet interpolation, and an isokinetic fatigue test.
resultsParticipants with high-PD motor signs had significantly more quadriceps weakness and central activation deficits than those with low-PD motor signs or healthy controls. Strength and activation deficits correlated strongly with UPDRS motor score. Quadriceps muscle fatigue was present in healthy controls and in those with low-PD motor signs but not in those with high-PD motor signs.
conclusionsThese findings provide additional evidence for lower-extremity strength loss with PD; central activation deficits may account for some of the strength deficits, especially with increased PD motor signs. Also, muscle fatigue did not occur in individuals with a greater degree of PD motor signs, most likely because of insufficient central activation to allow for muscle overload to induce metabolic fatigue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.