ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Mapping 3-D functional capillary geometry in rat skeletal muscle in vivo.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Pericytes in mouse heart.Frontiers in physiology · 2025Article
- Development of thin-film micro-outlets for spatially constraining local POFrontiers in physiology · 2025Article
- Skeletal muscle microvascular hemodynamic responses during hyperinsulinemic-euglycemic clamp in a Zucker Diabetic Sprague Dawley rat model of type 2 diabetes.Frontiers in physiology · 2025Article
- Capillary oxygen regulates demand-supply coupling by triggering connexin40-mediated conduction: Rethinking the metabolic hypothesis.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Capillary-Mitochondrial Oxygen Transport in Muscle: Paradigm Shifts.Function (Oxford, England) · 2023Review
- Dynamics of capillary blood flow responses to acute local changes in oxygen and carbon dioxide concentrations.Frontiers in physiology · 2022Article
- Do skeletal muscle motor units and microvascular units align to help match blood flow to metabolic demand?European journal of applied physiology · 2021Review
- Localized Oxygen Exchange Platform for Intravital Video Microscopy Investigations of Microvascular Oxygen Regulation.Frontiers in physiology · 2021Article
- Edward F. Adolph Distinguished Lecture. Contemporary model of muscle microcirculation: gateway to function and dysfunction.Journal of applied physiology (Bethesda, Md. : 1985) · 2019Review
- A simple automated method for continuous fieldwise measurement of microvascular hemodynamics.Microvascular research · 2019Article
- Capillary Network Morphometry of Pig Soleus Muscle Significantly Changes in 24 Hours After Death.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2018Article
- Krogh-cylinder and infinite-domain models for washout of an inert diffusible solute from tissue.Microcirculation (New York, N.Y. : 1994) · 2015Article
- Comparison of generated parallel capillary arrays to three-dimensional reconstructed capillary networks in modeling oxygen transport in discrete microvascular volumes.Microcirculation (New York, N.Y. : 1994) · 2013Article
- Oxygen transport in the microcirculation and its regulation.Microcirculation (New York, N.Y. : 1994) · 2013Review
- Microvascular flow modeling using in vivo hemodynamic measurements in reconstructed 3D capillary networks.Microcirculation (New York, N.Y. : 1994) · 2012Article
- Toward a multiscale description of microvascular flow regulation: o(2)-dependent release of ATP from human erythrocytes and the distribution of ATP in capillary networks.Frontiers in physiology · 2012Article
Corrections and comments
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Authors and funding
4 authors.
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Abstract
We have developed a novel mapping software package to reconstruct microvascular networks in three dimensions (3-D) from in vivo video images for use in blood flow and O2 transport modeling. An intravital optical imaging system was used to collect video sequences of blood flow in microvessels at different depths in the tissue. Functional images of vessels were produced from the video sequences and were processed using automated edge tracking software to yield location and geometry data for construction of the 3-D network. The same video sequences were analyzed for hemodynamic and O2 saturation data from individual capillaries in the network. Simple user-driven commands allowed the connection of vessel segments at bifurcations, and semiautomated registration enabled the tracking of vessels across multiple focal planes and fields of view. The reconstructed networks can be rotated and manipulated in 3-D to verify vessel connections and continuity. Hemodynamic and O2 saturation measurements made in vivo can be indexed to corresponding vessels and visualized using colorized maps of the vascular geometry. Vessels in each reconstruction are saved as text-based files that can be easily imported into flow or O2 transport models with complete geometry, hemodynamic, and O2 transport conditions. The results of digital morphometric analysis of seven microvascular networks showed mean capillary diameters and overall capillary density consistent with previous findings using histology and corrosion cast techniques. The described mapping software is a valuable tool for the quantification of in vivo microvascular geometry, hemodynamics, and oxygenation, thus providing rich data sets for experiment-based computational models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.