ReviewGenesis (New York, N.Y. : 2000)2012
The epigenome in early vertebrate development.
Review in Genesis (New York, N.Y. : 2000), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Genomic Profiling of Chromatin State Using CUT&Tag.Methods in molecular biology (Clifton, N.J.) · 2027Article
- Article
- Dna methylation dynamics associated with visual system remodeling during flatfish metamorphosis.Epigenetics & chromatin · 2025Article
- Epigenetics of prenatal stress in humans: the current research landscape.Clinical epigenetics · 2024Review
- A systemic cell cycle block impacts stage-specific histone modification profiles during Xenopus embryogenesis.PLoS biology · 2021Article
- Combinatorial transcription factor activities on open chromatin induce embryonic heterogeneity in vertebrates.The EMBO journal · 2021Article
- DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain.Developmental biology · 2020Article
- Histone Modifications of H3K4me3, H3K9me3 and Lineage Gene Expressions in Chimeric Mouse Embryo.Cell journal · 2020Article
- Analysis of zebrafish periderm enhancers facilitates identification of a regulatory variant near humaneLife · 2020Article
- Nucleoplasmin is a limiting component in the scaling of nuclear size with cytoplasmic volume.The Journal of cell biology · 2019Article
- Tissue-specific DNA methylation is conserved across human, mouse, and rat, and driven by primary sequence conservation.BMC genomics · 2017Article
- Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.Developmental cell · 2017Article
- Hypoxia increases genome-wide bivalent epigenetic marking by specific gain of H3K27me3.Epigenetics & chromatin · 2016Article
- Establishing pluripotency in early development.Biochimica et biophysica acta · 2015Review
- Snail2/Slug cooperates with Polycomb repressive complex 2 (PRC2) to regulate neural crest development.Development (Cambridge, England) · 2015Article
- NFATc2 mediates epigenetic modification of dendritic cell cytokine and chemokine responses to dectin-1 stimulation.Nucleic acids research · 2015Article
- Principles of nucleation of H3K27 methylation during embryonic development.Genome research · 2014Article
- Polycomb repressive complex PRC2 regulates Xenopus retina development downstream of Wnt/β-catenin signaling.Development (Cambridge, England) · 2013Article
- Differential transcript isoform usage pre- and post-zygotic genome activation in zebrafish.BMC genomics · 2013Article
- CBS: an open platform that integrates predictive methods and epigenetics information to characterize conserved regulatory features in multiple Drosophila genomes.BMC genomics · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Epigenetic regulation defines the commitment and potential of cells, including the limitations in their competence to respond to inducing signals. This review discusses the developmental origins of chromatin state in Xenopus and other vertebrate species and provides an overview of its use in genome annotation. In most metazoans the embryonic genome is transcriptionally quiescent after fertilization. This involves nucleosome-dense chromatin, repressors and a temporal deficiency in the transcription machinery. Active histone modifications such as H3K4me3 appear in pluripotent blastula embryos, whereas repressive marks such as H3K27me3 show a major increase in enrichment during late blastula and gastrula stages. The H3K27me3 modification set by Polycomb restricts ectopic lineage-specific gene expression. Pluripotent chromatin in Xenopus embryos is relatively unconstrained, whereas the pluripotent cell lineage in mammalian embryos harbors a more enforced type of pluripotent chromatin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.