ArticleNucleic acids research2012
VIRsiRNAdb: a curated database of experimentally validated viral siRNA/shRNA.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Therapeutic Approaches of Viral Gene Silencing by Small Interfering RNA: Strategies to Prevent the Emergence of Antiviral Resistant Escape Mutants.Pharmaceuticals (Basel, Switzerland) · 2025Review
- siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database.IET systems biology · 2024Article
- Current Development of Data Resources and Bioinformatics Tools for Anticoronavirus Peptide.Current medicinal chemistry · 2024Review
- Review
- SMRI: A New Method for siRNA Design for COVID-19 Therapy.Journal of computer science and technology · 2022Article
- In Silico Methods for the Identification of Viral-Derived Small Interfering RNAs (vsiRNAs) and Their Application in Plant Genomics.Methods in molecular biology (Clifton, N.J.) · 2022Article
- A SARS-CoV-2 targeted siRNA-nanoparticle therapy for COVID-19.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Article
- From genomes to molecular dynamics - A bottom up approach in extrication of SARS CoV-2 main protease inhibitors.Computational toxicology (Amsterdam, Netherlands) · 2021Article
- A small interfering RNA (siRNA) database for SARS-CoV-2.Scientific reports · 2021Article
- Viral Vectors Applied for RNAi-Based Antiviral Therapy.Viruses · 2020Review
- A review on current status of antiviral siRNA.Reviews in medical virology · 2018Review
- aBiofilm: a resource of anti-biofilm agents and their potential implications in targeting antibiotic drug resistance.Nucleic acids research · 2018Article
- PVsiRNAdb: a database for plant exclusive virus-derived small interfering RNAs.Database : the journal of biological databases and curation · 2018Article
- Time-series oligonucleotide count to assign antiviral siRNAs with long utility fit in the big data era.Gene therapy · 2017Article
- ASPsiRNA: A Resource of ASP-siRNAs Having Therapeutic Potential for Human Genetic Disorders and Algorithm for Prediction of Their Inhibitory Efficacy.G3 (Bethesda, Md.) · 2017Article
- A database of breast oncogenic specific siRNAs.Scientific reports · 2017Article
- AVCpred: an integrated web server for prediction and design of antiviral compounds.Chemical biology & drug design · 2017Article
- Directional and reoccurring sequence change in zoonotic RNA virus genomes visualized by time-series word count.Scientific reports · 2016Article
- SMEpred workbench: A web server for predicting efficacy of chemicallymodified siRNAs.RNA biology · 2016Article
- ZikaVR: An Integrated Zika Virus Resource for Genomics, Proteomics, Phylogenetic and Therapeutic Analysis.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
RNAi technology has been emerging as a potential modality to inhibit viruses during past decade. In literature a few siRNA databases have been reported that focus on targeting human and mammalian genes but experimentally validated viral siRNA databases are lacking. We have developed VIRsiRNAdb, a manually curated database having comprehensive details of 1358 siRNA/shRNA targeting viral genome regions. Further, wherever available, information regarding alternative efficacies of above 300 siRNAs derived from different assays has also been incorporated. Important fields included in the database are siRNA sequence, virus subtype, target genome region, cell type, target object, experimental assay, efficacy, off-target and siRNA matching with reference viral sequences. Database also provides the users with facilities of advance search, browsing, data submission, linking to external databases and useful siRNA analysis tools especially siTarAlign which align the siRNA with reference viral genomes or user defined sequences. VIRsiRNAdb contains extensive details of siRNA/shRNA targeting 42 important human viruses including influenza virus, hepatitis B virus, HPV and SARS Corona virus. VIRsiRNAdb would prove useful for researchers in picking up the best viral siRNA for antiviral therapeutics development and also for developing better viral siRNA design tools. The database is freely available at http://crdd.osdd.net/servers/virsirnadb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.