ArticleNucleic acids research2012
Mre11 modulates the fidelity of fusion between short telomeres in human cells.
Article in Nucleic acids research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Telomere Crisis Shapes Cancer Evolution.Cold Spring Harbor perspectives in biology · 2026Review
- DNA Repair Mechanisms, Protein Interactions and Therapeutic Targeting of the MRN Complex.Cancers · 2022Review
- Article
- High-throughput STELA provides a rapid test for the diagnosis of telomere biology disorders.Human genetics · 2021Article
- Chromosome instability induced by a single defined sister chromatid fusion.Life science alliance · 2020Article
- DNA polymerase theta (Polθ) - an error-prone polymerase necessary for genome stability.Current opinion in genetics & development · 2020Review
- PARP inhibition prevents escape from a telomere-driven crisis and inhibits cell immortalisation.Oncotarget · 2018Article
- Telomeres and genomic evolution.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Review
- Telomere fusion threshold identifies a poor prognostic subset of breast cancer patients.Molecular oncology · 2015Article
- Spontaneous telomere to telomere fusions occur in unperturbed fission yeast cells.Nucleic acids research · 2013Article
- Alternative end-joining mechanisms: a historical perspective.Frontiers in genetics · 2013Article
- Alternative end joining, clonal evolution, and escape from a telomere-driven crisis.Molecular & cellular oncologyArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The loss of telomere function can result in the fusion of telomeres with other telomeric loci, or non-telomeric double-stranded DNA breaks. Sequence analysis of fusion events between short dysfunctional telomeres in human cells has revealed that fusion is characterized by a distinct molecular signature consisting of extensive deletions and micro-homology at the fusion points. This signature is consistent with alternative error-prone end-joining processes. We have examined the role that Mre11 may play in the fusion of short telomeres in human cells; to do this, we have analysed telomere fusion events in cells derived from ataxia-telangiectasia-like disorder (ATLD) patients that exhibit hypomorphic mutations in MRE11. The telomere dynamics of ATLD fibroblasts were indistinguishable from wild-type fibroblasts and they were proficient in the fusion of short telomeres. However, we observed a high frequency of insertion of DNA sequences at the fusion points that created localized sequence duplications. These data indicate that Mre11 plays a role in the fusion of short dysfunctional telomeres in human cells and are consistent with the hypothesis that as part of the MRN complex it serves to stabilize the joining complex, thereby controlling the fidelity of the fusion reaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.