ArticleHuman brain mapping2013
Body mass index correlates negatively with white matter integrity in the fornix and corpus callosum: a diffusion tensor imaging study.
Article in Human brain mapping, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 1 of them a synthesis that pooled it.
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Who cites it
80 citing papers in PubMed, 1 synthesis or guideline pooled it, 148 citations in OpenAlex.
- Altered White Matter Microstructures in Type 2 Diabetes Mellitus: A Coordinate-Based Meta-Analysis of Diffusion Tensor Imaging Studies.Frontiers in endocrinology · 2021Pooled it
- Trial
- White matter changes associated with antipsychotic treatment in first-episode psychosis.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2014Trial
- Impact of physical activity and exercise interventions on white matter integrity in overweight and obese populations: A systematic review and meta-analysis.Comprehensive psychoneuroendocrinology · 2026Review
- Causal relationship between obesity, leptin, and brain structure and functional connectivity: evidence based on bidirectional and mediation mendelian randomisation analyses.Nutrition & metabolism · 2026Article
- Cognitive Implications of White Matter Alterations in Overweight Chinese Individuals: An NODDI and DTI Study.Brain and behavior · 2025Article
- Association of Diet and Waist-to-Hip Ratio With Brain Connectivity and Memory in Aging.JAMA network open · 2025Article
- Similarities and Differences in Neuroimaging.Advances in experimental medicine and biology · 2025Review
- Structural connectome manifold changes related to body mass index and their associations with eating psychopathology.NeuroImage. Clinical · 2025Article
- The association between small vessel disease and obstructive sleep apnea: a peak width of skeletonized mean diffusivity-based study.Sleep & breathing = Schlaf & Atmung · 2024Article
- Longitudinal evidence for a mutually reinforcing relationship between white matter hyperintensities and cortical thickness in cognitively unimpaired older adults.Alzheimer's research & therapy · 2024Article
- Edge Density Imaging Identifies White Matter Biomarkers of Late-Life Obesity and Cognition.Aging and disease · 2024Article
- Leptin receptor reactivation restores brain function in early-life Lepr-deficient mice.Brain : a journal of neurology · 2024Article
- Childhood obesity's effect on cognition and brain connectivity worsens with low family income.JCI insight · 2024Article
- Association of body-mass index with physiological brain pulsations across adulthood - a fast fMRI study.International journal of obesity (2005) · 2024Article
- Article
- White adipose tissue distribution and amount are associated with increased white matter connectivity.Human brain mapping · 2024Article
- Diffusion tensor imaging findings in the hunger and satiety centers of the brain after bariatric surgery: a preliminary study.Irish journal of medical science · 2024Article
- Novel insights into brain lipid metabolism in Alzheimer's disease: Oligodendrocytes and white matter abnormalities.FEBS open bio · 2024Review
- Influence of mild cognitive impairment and body mass index on white matter integrity assessed by diffusion tensor imaging.Psychophysiology · 2023Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Overweight or obese body habitus is associated with cognitive deficits, impaired brain function, gray matter atrophy, and white matter (WM) hyperintensities. However, few diffusion tensor imaging (DTI) studies have assessed WM integrity in relation to overweight or obese status. This study assessed relationships between body mass index (BMI) and values of DTI parameters among 51 normal weight (lean), overweight, and obese participants who were otherwise healthy. BMI correlated negatively with fractional anisotropy and axial eigenvalues (λ(1)) in the body of corpus callosum (CC), positively with mean diffusivity and radial eigenvalues (See figure in text) in the fornix and splenium of CC, and positively with λ(1) in the right corona radiata (CR) and superior longitudinal fasciculus (SLF). These data indicate that BMI correlates negatively with WM integrity in the fornix and CC. Furthermore, the different patterns of BMI-related differences in DTI parameters at the fornix, body, and splenium of the CC, and the right CR and SLF suggest that different biological processes may underlie BMI-related impairments of WM integrity in different brain regions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.