Evidence map›Paper›PMID 22139528›Full record

ReviewCurrent cardiology reports2012

Tight blood pressure control in diabetes: evidence-based review of treatment targets in patients with diabetes.

Gianpaolo Reboldi, Giorgio Gentile, Valeria Maria Manfreda, Fabio Angeli, Paolo Verdecchia

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current cardiology reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 4 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.

  1. Treatment of Diabetes in Older Adults: An Endocrine Society* Clinical Practice Guideline.The Journal of clinical endocrinology and metabolism · 2019
    Guideline
  2. Clinical Significance of Arterial Stiffness and Thickness Biomarkers in Type 2 Diabetes Mellitus: An Up-To-Date Meta-Analysis.Medical science monitor : international medical journal of experimental and clinical research · 2015
    Pooled it
  3. Pooled it
  4. Pooled it
  5. Observational
  6. Review
  7. Review
  8. Article
  9. Blood pressure j-curve: current concepts.Current hypertension reports · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Gianpaolo ReboldiDepartment of Internal Medicine, University of Perugia, Via E. Dal Pozzo, 06126 Perugia, Italy. paolo@unipg.it
Giorgio Gentile
Valeria Maria Manfreda
Fabio Angeli
Paolo Verdecchia
University of Perugia · ITAssisi Foundation of Memphis · USAzienda Ospedaliera Bolognini Seriate · ITOspedale Santa Maria · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood pressure (BP) targets in diabetic patients stills represent the object of a major debate, fueled by the recent publication of post hoc observational analyses of the INVEST and the ONTARGET trials, suggesting an increased risk of cardiovascular events with tighter control, the J-curve effect, and by the results of the ACCORD trial, showing no improvements in the composite primary outcome of nonfatal myocardial infarction, stroke, or cardiovascular death in the intensive BP-lowering arm (<120/80 mmHg). In the present review, we focus on existing evidence about different BP targets in diabetic subjects and we present the results of our recent meta-analysis, showing that tight BP control may significantly reduce the risk of stroke in these patients without increasing the risk of myocardial infarction. Therapeutic inertia (leaving diabetic patients with BP values of 140/90 mmHg or higher) should be avoided at all costs, as this would lead to an unacceptable toll in terms of human lives, suffering, and socioeconomic costs.

Indexed as

Blood PressureAntihypertensive AgentsBlood Pressure DeterminationDiabetes Mellitus, Type 2Diabetic AngiopathiesEvidence-Based MedicineFemaleHumansHypertensionMaleMeta-Analysis as TopicMyocardial InfarctionRandomized Controlled Trials as TopicStrokeAntihypertensive Agents

Identifiers

PMID22139528
OpenAlexW1975781578

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.