ArticleOrigins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life2011
May cyclic nucleotides be a source for abiotic RNA synthesis?
Article in Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Significant impacts of metal ions from ancient oceans on nucleoside phosphorylation.BMC chemistry · 2025Article
- Potential pitfalls in MALDI-TOF MS analysis of abiotically synthesized RNA oligonucleotides.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2013Article
- The role of energy in the emergence of biology from chemistry.Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life · 2012Article
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5 authors.
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Abstract
Nucleic bases are obtained by heating formamide in the presence of various catalysts. Formamide chemistry also allows the formation of acyclonucleosides and the phosphorylation of nucleosides in every possible position, also affording 2',3' and 3',5' cyclic forms. We have reported that 3',5' cyclic GMP and 3',5' cyclic AMP polymerize in abiotic conditions yielding short oligonucleotides. The characterization of this reaction is being pursued, several of its parameters have been determined and experimental caveats are reported. The yield of non-enzymatic polymerization of cyclic purine nucleotides is very low. Polymerization is strongly enhanced by the presence of base-complementary RNA sequences.
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