ArticleOptics letters2011
In vivo confocal imaging of fast intrinsic optical signals correlated with frog retinal activation.
Article in Optics letters, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 19 citations in OpenAlex.
- Polarization optical coherence tomography optoretinography: verifying light-induced photoreceptor outer segment shrinkage and subretinal space expansion.Neurophotonics · 2025Article
- Fast intrinsic optical signal correlates with activation phase of phototransduction in retinal photoreceptors.Experimental biology and medicine (Maywood, N.J.) · 2020Review
- Imaging Retinal Activity in the Living Eye.Annual review of vision science · 2019Review
- Stimulus-evoked outer segment changes occur before the hyperpolarization of retinal photoreceptors.Biomedical optics express · 2017Article
- In vivo optical coherence tomography of stimulus-evoked intrinsic optical signals in mouse retinas.Journal of biomedical optics · 2016Article
- Stimulus-evoked outer segment changes in rod photoreceptors.Journal of biomedical optics · 2016Article
- Article
- Biophysical mechanism of transient retinal phototropism in rod photoreceptors.Proceedings of SPIE--the International Society for Optical Engineering · 2016Article
- Intrinsic optical signal imaging of retinal physiology: a review.Journal of biomedical optics · 2015Review
- Functional optical coherence tomography enables in vivo physiological assessment of retinal rod and cone photoreceptors.Scientific reports · 2015Article
- Super-Resolution Scanning Laser Microscopy Based on Virtually Structured Detection.Critical reviews in biomedical engineering · 2015Review
- Digital adaptive optics line-scanning confocal imaging system.Journal of biomedical optics · 2015Article
- En face optical coherence tomography of transient light response at photoreceptor outer segments in living frog eyecup.Optics letters · 2013Article
- Super-resolution scanning laser microscopy through virtually structured detection.Biomedical optics express · 2013Article
- In vivo confocal intrinsic optical signal identification of localized retinal dysfunction.Investigative ophthalmology & visual science · 2012Article
- Dynamic intrinsic optical signal monitoring of electrically stimulated inner retinal neural response.Journal of modern optics · 2012Article
- Comparative intrinsic optical signal imaging of wild-type and mutant mouse retinas.Optics express · 2012Article
- Shining light on photoreceptors: A minireview on the development and clinical applications of optoretinography.Taiwan journal of ophthalmologyReview
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Using freshly isolated animal retinas, we have conducted a series of experiments to test fast intrinsic optical signals (IOSs) that have time courses comparable to electrophysiological kinetics. In this Letter, we demonstrate the feasibility of in vivo imaging of fast IOSs in intact frogs. A rapid line-scan confocal ophthalmoscope was constructed to achieve high-speed IOS recording. By rejecting out-of-focus background light, the line-scan confocal imager provided the resolution to differentiate individual photoreceptors in vivo. Rapid confocal imaging disclosed robust IOSs with time courses comparable to retinal electroretinogram kinetics. High-resolution IOS images revealed both positive (increasing) and negative (decreasing) light responses, with subcellular complexity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.