Evidence map›Paper›PMID 22138498›Full record

ArticleCellular immunology2012

Modulation of TCRβ surface expression during TCR revision.

Kalynn B Simmons, Maramawit Wubeshet, Kristina T Ames, Catherine J McMahan, J Scott Hale, Pamela J Fink

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Review
  3. Receptor revision in CD4 T cells is influenced by follicular helper T cell formation and germinal-center interactions.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Kalynn B SimmonsDepartment of Immunology, University of Washington, Seattle, WA, USA.
Maramawit Wubeshet
Kristina T Ames
Catherine J McMahan
J Scott Hale
Pamela J Fink
University of Washington · US

Funding

BASIC IMMUNOLOGYT32CA009537 · NCI · UNIVERSITY OF WASHINGTON · PI GOVERMAN, JOAN M · 1986 to 2012
$3.1M
SELECTION OF THE T RECEPTOR REPERTOIRER01AG013078 · NIA · UNIVERSITY OF WASHINGTON · PI FINK, PAMELA J · 1994 to 2011
$2.8M
NCI NIH HHS T32 CA009537NCI NIH HHS T32 CA09537NIA NIH HHS R01 AG013078NIA NIH HHS R01 AG13078
6 · The paper itself

Abstract

TCR revision is a tolerance mechanism by which self-reactive TCRs expressed by mature CD4(+) peripheral T cells are replaced by receptors encoded by genes generated by post-thymic DNA rearrangement. The downmodulation of surface TCR expression initiates TCR revision, and serves as a likely trigger for the induction of the recombinase machinery. We show here in a Vβ5 transgenic mouse model system that downregulation of the self-reactive transgene-encoded TCR is not maintained by transgene loss or diminished transcription or translation. The downregulation of surface TCR expression likely occurs in two stages, only one of which requires tolerogen expression.

Indexed as

Gene Rearrangement, beta-Chain T-Cell Antigen ReceptorAnimalsCD4-Positive T-LymphocytesDown-RegulationGene ExpressionImmune ToleranceMiceMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaTransgenesReceptors, Antigen, T-Cell, alpha-beta

Identifiers

PMID22138498
PMCPMC3244515
OpenAlexW2025140787

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.