Evidence map›Paper›PMID 22138231›Full record

ReviewTrends in cognitive sciences2012

Obsessive-compulsive disorder: beyond segregated cortico-striatal pathways.

Mohammed R Milad, Scott L Rauch

4 registry-linked trialsOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Trends in cognitive sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 376 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
376citing papers in PubMed, 15 pooled it
28.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03348930 phase2 / phase3completednot on this mapstarted 2018, after this paper: background citation

Tolcapone Treatment of Obsessive Compulsive Disorder: A Double-Blind, Placebo-Controlled, Cross-Over Pilot Study

TypeinterventionalSponsorUniversity of ChicagoRan2018 to 2020Enrolled20ConditionsObsessive-Compulsive DisorderArmsTolcapone 200 MG
NCT04958096 narecruitingnot on this mapstarted 2021, after this paper: background citation

Adjunct Cortical Stimulation With Deep Brain Stimulation (DBS) to Treat Obsessive Compulsive Disorder (OCD)

TypeinterventionalSponsorAndrew Moses Lee, MD, PhDRan2021 to 2026Enrolled15ConditionsObsessive-Compulsive DisorderArmsStandard Therapeutic Deep Brain Stimulation, Cortical Stimulation for PFC, Cortical Stimulation for ACC
NCT05015595 phase3unknown statusnot on this mapstarted 2021, after this paper: background citation

Memantine for Refractory OCD Patients: a Pragmatic Double Blind, Randomized, Parallel Group, Placebo Controlled, Monocentric Trial

TypeinterventionalSponsorUniversity of Roma La SapienzaRan2021 to 2022Enrolled20ConditionsObsessive-Compulsive DisorderArmsMemantine Oral Tablet, Placebo
NCT06566781 recruitingnot on this mapstarted 2019, after this paper: background citation

Reinforcement Learning and Obsessive-compulsive Disorder: Exploring the Role of the Orbitofrontal Cortex

TypeobservationalSponsorFundacao ChampalimaudRan2019 to 2026Enrolled230ConditionsObsessive-Compulsive Disorder
3 · Its place in the literature

Who cites it

376 citing papers in PubMed, 15 syntheses or guidelines pooled it, 844 citations in OpenAlex.

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  14. Invasive and Non-invasive Neurostimulation for OCD.Current topics in behavioral neurosciences · 2021
    Pooled it
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  16. Efficacy and safety of transcranial direct current stimulation as an add-on treatment for obsessive-compulsive disorder: a randomized, sham-controlled trial.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021
    Trial
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  18. Theta burst stimulation for the treatment of obsessive-compulsive disorder: a pilot study.Journal of neural transmission (Vienna, Austria : 1996) · 2019
    Trial
  19. Article
  20. Distinct structural abnormalities in obsessive-compulsive and alcohol use disorders.European archives of psychiatry and clinical neuroscience · 2026
    Article

316 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Mohammed R MiladDepartment of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA. milad@nmr.mgh.harvard.edu
Scott L Rauch
Harvard University · USMcLean Hospital · US

Funding

Translational Studies of Prefrontal Control of Fear ExtinctionR01MH081975 · NIMH · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI QUIRK, GREGORY J · 2009 to 2013
$3.3M
NIMH NIH HHS R01 MH081975NIMH NIH HHS R01-MH081975
6 · The paper itself

Abstract

Obsessive-compulsive disorder (OCD) affects approximately 2-3% of the population and is characterized by recurrent intrusive thoughts (obsessions) and repetitive behaviors or mental acts (compulsions), typically performed in response to obsessions or related anxiety. In the past few decades, the prevailing models of OCD pathophysiology have focused on cortico-striatal circuitry. More recent neuroimaging evidence, however, points to critical involvement of the lateral and medial orbitofrontal cortices, the dorsal anterior cingulate cortex and amygdalo-cortical circuitry, in addition to cortico-striatal circuitry, in the pathophysiology of the disorder. In this review, we elaborate proposed features of OCD pathophysiology beyond the classic parallel cortico-striatal pathways and argue that this evidence suggests that fear extinction, in addition to behavioral inhibition, is impaired in OCD.

Indexed as

AmygdalaAnxiety DisordersCerebral CortexCompulsive BehaviorCorpus StriatumHumansNeuroimagingObsessive-Compulsive Disorder

Identifiers

PMID22138231
PMCPMC4955838
OpenAlexW2159370497

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.