ArticleDevelopmental biology2012
Some, but not all, retromer components promote morphogenesis of C. elegans sensory compartments.
Article in Developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Glia Development and Function in the NematodeCold Spring Harbor perspectives in biology · 2024Review
- Neuron cilia restrain glial KCC-3 to a microdomain to regulate multisensory processing.Cell reports · 2024Article
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- C. elegans as a model to study glial development.The FEBS journal · 2022Review
- DYF-4 regulates patched-related/DAF-6-mediated sensory compartment formation in C. elegans.PLoS genetics · 2021Article
- Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.PLoS genetics · 2021Article
- Review
- Review
- Morphogenesis of neurons and glia within an epithelium.Development (Cambridge, England) · 2019Article
- To degrade or not to degrade: mechanisms and significance of endocytic recycling.Nature reviews. Molecular cell biology · 2018Review
- Sorting nexin 3 mutation impairs development and neuronal function in Caenorhabditis elegans.Cellular and molecular life sciences : CMLS · 2018Article
- Antagonistic regulation of trafficking toProceedings of the National Academy of Sciences of the United States of America · 2018Article
- IGDB-2, an Ig/FNIII protein, binds the ion channel LGC-34 and controls sensory compartment morphogenesis in C. elegans.Developmental biology · 2017Article
- Glial development and function in the nervous system of Caenorhabditis elegans.Cold Spring Harbor perspectives in biology · 2015Review
- C. elegans as a model for membrane traffic.WormBook : the online review of C. elegans biology · 2014Review
- On the morphogenesis of glial compartments in the sensory organs of Caenorhabditis elegans.Worm · 2012Article
- Cell-type-specific promoters forJournal of neurogeneticsArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The endings of sensory receptor cells often lie within specialized compartments formed by glial cells. The main sensory organ of Caenorhabditis elegans, the amphid, provides a powerful setting for studying glial compartment morphogenesis. Our previous studies showed that amphid compartment size is controlled by opposing activities of the Nemo-like kinase LIT-1, which promotes compartment expansion, and the Patched-related protein DAF-6, which restricts compartment growth. From a genetic screen for mutations able to suppress the bloated sensory compartments of daf-6 mutants, we identified an allele of the sorting nexin gene snx-1. SNX-1 protein is a component of the retromer, a protein complex that facilitates recycling of transmembrane proteins from the endosome to the Golgi network. We find that snx-1 functions cell autonomously within glia to promote sensory compartment growth, and that SNX-1 protein is enriched near the surface of the sensory compartment. snx-1 interacts genetically with lit-1 and another regulator of compartment size, the Dispatched-related gene che-14. Mutations in snx-3 and vps-29, also retromer genes, can suppress daf-6 defects. Surprisingly, however, remaining retromer components seem not to be involved. Our results suggest that a novel assembly of retromer components is important for determining sensory compartment dimensions.
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