Evidence map›Paper›PMID 22137639›Full record

ReviewTrends in cardiovascular medicine2010

Role of molecular imaging in stem cell therapy for myocardial restoration.

Maarten A Lijkwan, Ernst Jan Bos, Joseph C Wu, Robert C Robbins

Abstract readReview
In one paragraph

Review in Trends in cardiovascular medicine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Development of new technologies for stem cell research.Journal of biomedicine & biotechnology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Maarten A LijkwanDepartment of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
Ernst Jan Bos
Joseph C Wu
Robert C Robbins

Funding

Induced pluripotent stem cells in the understanding and treatment of heart diseaseU01HL099776 · NHLBI · STANFORD UNIVERSITY · PI LONGAKER, MICHAEL T, WU, JOSEPH C. · 2009 to 2015
$8.2M
Molecular Imaging of Cardiac Stem Cell TherapyR01EB009689 · NIBIB · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2010 to 2013
$1.4M
Molecular Imaging of Resident Cardiac Stem CellsRC1HL099117 · NHLBI · STANFORD UNIVERSITY · PI WU, JOSEPH C. · 2009 to 2010
$1000k
NHLBI NIH HHS RC1 HL099117NHLBI NIH HHS U01 HL099776NIBIB NIH HHS R01 EB009689
6 · The paper itself

Abstract

During the past two decades, stem cells have created enthusiasm as a regenerative therapy for ischemic heart disease. Transplantation of bone marrow stem cells, skeletal myoblasts, and endothelial progenitor cells has shown to improve myocardial function after infarction. Recently, attention has focused on the potential use of embryonic stem cells and induced pluripotent stem cells because they possess the capacity to differentiate into various cell types, including cardiac and endothelial cells. Clinical trials have shown positive effects on the functional recovery of heart after myocardial infarction and have answered questions on timing, dosage, and cell delivery route of stem cells such as those derived from bone marrow. Despite the current advances in stem cell research, one main hurdle remains the lack of reliable information about the fate of cell engraftment, survival, and proliferation after transplantation. This review discusses the different cell types used in cardiac cell therapy as well as molecular imaging modalities relevant to survival issues.

Indexed as

AnimalsDisease Models, AnimalHumansLuminescent MeasurementsMagnetic Resonance ImagingMolecular ImagingMyocardial InfarctionMyocardial IschemiaPositron-Emission TomographyStem Cell Transplantation

Identifiers

PMID22137639
PMCPMC3625429

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.