Evidence map›Paper›PMID 22137208›Full record

ArticleAmerican journal of ophthalmology2012

Progressive constriction of the hyperautofluorescent ring in retinitis pigmentosa.

Luiz H Lima, Tomas Burke, Vivienne C Greenstein, Chai Lin Chou, Wener Cella, Lawrence A Yannuzzi, Stephen H Tsang

Open access · bronzeAbstract read
In one paragraph

Article in American journal of ophthalmology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

  1. Pooled it
  2. Atypical retinitis pigmentosa associated withAmerican journal of ophthalmology case reports · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Observational
  11. Primary versus Secondary Elevations in Fundus Autofluorescence.International journal of molecular sciences · 2023
    Review
  12. Article
  13. Article
  14. The Natural History ofInternational journal of molecular sciences · 2022
    Article
  15. Article
  16. Investigating Biomarkers forInternational journal of molecular sciences · 2022
    Article
  17. Review
  18. Review
  19. Article
  20. Central Serous Chorioretinopathy Analyzed by Multimodal Imaging.Translational vision science & technology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Luiz H LimaVitreous, Retina, Macula Consultants of New York, New York, New York 10032, USA.
Tomas Burke
Vivienne C Greenstein
Chai Lin Chou
Wener Cella
Lawrence A Yannuzzi
Stephen H Tsang
Columbia University · USManhattan Eye, Ear and Throat Hospital · USVitreous Retina Macula Consultants of New York · US

Funding

Instrumentation, Fabrication, and Design CoreP30EY019007 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Xin Zhang · 2010 to 2026
$12.9M
MEASURES OF HUMAN RECEPTOR AND POST RECEPTOR ACTIVITYR01EY009076 · NEI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI BIRCH, DAVID G, HOOD, DONALD C. · 1991 to 2021
$8.3M
Genetic Variation in Age-Related Macular DegenerationR01EY013435 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALLIKMETS, RANDO L · 2001 to 2014
$7.7M
Tests of Models of Retinal/Optic Nerve Diseases&AdaptionR01EY002115 · NEI · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI HOOD, DONALD C. · 1985 to 2018
$7.4M
Toward mechanism- and gene-based therapies for retinal degenerationR01EY018213 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stephen H Tsang · 2008 to 2026
$6.6M
Validated Autofluorescence in Age-Related Macular DegenerationR01EY015520 · NEI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SMITH, ROLAND THEODORE · 2005 to 2018
$6.0M
Completing genetic analysis of the ABCA4 locusR01EY021163 · NEI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALLIKMETS, RANDO L · 2011 to 2014
$2.4M
NEI NIH HHS EY018213NEI NIH HHS EY021163NEI NIH HHS P30 EY019007NEI NIH HHS P30EY019007NEI NIH HHS R01 EY002115NEI NIH HHS R01 EY009076NEI NIH HHS R01 EY013435NEI NIH HHS R01 EY015520NEI NIH HHS R01 EY018213
6 · The paper itself

Abstract

purposeTo evaluate the constriction of the hyperautofluorescent ring over time in patients with retinitis pigmentosa (RP).

designProspective study.

methodsFourteen eyes of 14 RP patients with a hyperautofluorescent ring were studied. Ring constriction was evaluated by measurements of its external and internal boundaries along the vertical and horizontal axes at baseline and at 12-, 24-, 36-, and 48-month follow-ups. Repeat fundus autofluorescence was obtained at 12, 24, 36, and 48 months in 13, 7, 5, and 1 eyes respectively. Spectral-domain optical coherence tomography (SD-OCT) images were obtained on 8 eyes and the horizontal extent of the inner segment/outer segment (IS/OS) junction was measured. SD-OCT was repeated at 12 and 24 months in 6 and 4 eyes respectively.

resultsThe external boundaries of the ring were identified along the horizontal axis in 12 eyes and along the vertical axis in 13. Internal boundaries were identified in 7 eyes. Constriction was demonstrated in all patients except 1 who demonstrated minimal expansion of the internal boundary along the horizontal axis. SD-OCT measurements showed a decrease in the IS/OS junction length.

conclusionProgressive constriction of the hyperautofluorescent ring and a concordant decrease in IS/OS junction length were observed over time.

Indexed as

AdolescentAdultAgedChildCross-Sectional StudiesFluorescein AngiographyHumansMiddle AgedProspective StudiesRetinal Photoreceptor Cell Inner SegmentRetinal Photoreceptor Cell Outer SegmentRetinitis PigmentosaTomography, Optical CoherenceVisual AcuityVisual FieldsYoung Adult

Identifiers

PMID22137208
PMCPMC3830946
OpenAlexW2146122140

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.