Evidence map›Paper›PMID 22137187›Full record

ReviewSeminars in immunology2012

The role of B cells in solid organ transplantation.

Jean Kwun, Pinar Bulut, Eugenia Kim, Wasim Dar, Byoungchol Oh, Ravi Ruhil, Neal Iwakoshi, Stuart J Knechtle

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Seminars in immunology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. IRF4 ablation in B cells abrogates allogeneic B cell responses and prevents chronic transplant rejection.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2021
    Article
  5. Biomarkers in Solid Organ Transplantation.Clinics in laboratory medicine · 2019
    Review
  6. Article
  7. The immunological function of CD52 and its targeting in organ transplantation.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2017
    Review
  8. Review
  9. Lymphodepletional strategies in transplantation.Cold Spring Harbor perspectives in medicine · 2013
    Review
  10. Article
  11. Patterns of de novo allo B cells and antibody formation in chronic cardiac allograft rejection after alemtuzumab treatment.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2012
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Jean KwunEmory Transplant Center, Department of Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
Pinar Bulut
Eugenia Kim
Wasim Dar
Byoungchol Oh
Ravi Ruhil
Neal Iwakoshi
Stuart J Knechtle
Emory University · US

Funding

Transplant Tolerance in Non-Human PrimatesU19AI051731 · NIAID · UNIVERSITY OF WESTERN ONTARIO · PI ADAMS, ANDREW B · 2002 to 2022
$54.1M
Memory and Regulatory T Cells Following T Cell Depletion in TransplantationU01AI074635 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI KNECHTLE, STUART JOHNSTON · 2007 to 2011
$3.5M
NIAID NIH HHS U01 AI074635NIAID NIH HHS U01AI074635NIAID NIH HHS U19 AI051731
6 · The paper itself

Abstract

The role of antibodies in chronic injury to organ transplants has been suggested for many years, but recently emphasized by new data. We have observed that when immunosuppressive potency decreases either by intentional weaning of maintenance agents or due to homeostatic repopulation after immune cell depletion, the threshold of B cell activation may be lowered. In human transplant recipients the result may be donor-specific antibody, C4d+ injury, and chronic rejection. This scenario has precise parallels in a rhesus monkey renal allograft model in which T cells are depleted with CD3 immunotoxin, or in a CD52-T cell transgenic mouse model using alemtuzumab to deplete T cells. Such animal models may be useful for the testing of therapeutic strategies to prevent DSA. We agree with others who suggest that weaning of immunosuppression may place transplant recipients at risk of chronic antibody-mediated rejection, and that strategies to prevent this scenario are needed if we are to improve long-term graft and patient outcomes in transplantation. We believe that animal models will play a crucial role in defining the pathophysiology of antibody-mediated rejection and in developing effective therapies to prevent graft injury. Two such animal models are described herein.

Indexed as

Organ TransplantationAnimalsB-LymphocytesDisease Models, AnimalGraft RejectionHumansIsoantibodiesMacaca mulattaMiceRatsTransplantation ImmunologyIsoantibodies

Identifiers

PMID22137187
PMCPMC5504533
OpenAlexW2012507629

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.