ReviewExpert opinion on therapeutic targets2011
Convergent mechanisms in etiologically-diverse dystonias.
Review in Expert opinion on therapeutic targets, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Functional impact of the ATP1A3-p.A813V variant: insights into a calcium-driven hyperexcitability cascade in rapid-onset dystonia-Parkinsonism.Journal of translational medicine · 2026Article
- Purkinje cell intrinsic activity shapes cerebellar development and function.Nature communications · 2026Article
- Swept-Source Optical Coherence Tomography and Optical Coherence Tomography Angiography Findings in Patients with Solar Retinopathy.Beyoglu eye journal · 2025Article
- The Role of Serum Vitamin and Mineral Levels in Benign Essential Blepharospasm: A Comparative Study.Beyoglu eye journal · 2025Article
- Altered brain state during episodic dystonia in tottering mice decouples primary motor cortex from limb kinematics.Dystonia (Lausanne, Switzerland) · 2023Article
- Dystonia in veterinary neurology.Journal of veterinary internal medicine · 2022Review
- A Novel Variant of ATP5MC3 Associated with Both Dystonia and Spastic Paraplegia.Movement disorders : official journal of the Movement Disorder Society · 2022Article
- Serum calcium, magnesium, phosphorus, and vitamin D in benign essential blepharospasm.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2020Article
- The neurobiological basis for novel experimental therapeutics in dystonia.Neurobiology of disease · 2019Review
- The Anatomical Basis for Dystonia: The Motor Network Model.Tremor and other hyperkinetic movements (New York, N.Y.) · 2017Review
- Thiamine and dystonia 16.BMJ case reports · 2016Article
- ATP1A3 Mutation in Adult Rapid-Onset Ataxia.PloS one · 2016Article
- Article
- Diagnosis and treatment of dystonia.Neurologic clinics · 2015Review
- Reduced Number of Pigmented Neurons in the Substantia Nigra of Dystonia Patients? Findings from Extensive Neuropathologic, Immunohistochemistry, and Quantitative Analyses.Tremor and other hyperkinetic movements (New York, N.Y.) · 2015Article
- The New Classification System for the Dystonias: Why Was it Needed and How was it Developed?Movement disorders clinical practice · 2014Article
- Intragenic deletions affecting two alternative transcripts of the IMMP2L gene in patients with Tourette syndrome.European journal of human genetics : EJHG · 2014Article
- Dystonia type 6 gene product Thap1: identification of a 50 kDa DNA-binding species in neuronal nuclear fractions.Acta neuropathologica communications · 2014Article
- The focal dystonias: current views and challenges for future research.Movement disorders : official journal of the Movement Disorder Society · 2013Review
- Alternative approaches to modeling hereditary dystonias.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
introductionDystonia is a neurological disorder associated with twisting motions and abnormal postures, which compromise normal movements and can be both painful and debilitating. It can affect a single body part (focal), several contiguous regions (segmental), or the entire body (generalized), and can arise as a result of numerous causes, both genetic and acquired. Despite the diversity of causes and manifestations, shared clinical features suggest that common mechanisms of pathogenesis may underlie many dystonias. AREAS COVERED: Shared themes in etiologically-diverse dystonias exist at several biological levels. At the cellular level, abnormalities in the dopaminergic system, mitochondrial function and calcium regulation are often present. At the anatomical level, the basal ganglia and the cerebellum are frequently implicated. Global CNS dysfunction, specifically aberrant neuronal plasticity, inhibition and sensorimotor integration, are also observed in a number of dystonias. Using clinical data and data from animal models, this article seeks to highlight shared pathways that may be critical in understanding mechanisms and identifying novel therapeutic strategies in dystonia. EXPERT OPINION: Identifying shared features of pathogenesis can provide insight into the biological processes that underlie etiologically diverse dystonias, and can suggest novel targets for therapeutic intervention that may be effective in a broad group of affected individuals.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.