ArticleBiology direct2011
Transcription factor binding sites are highly enriched within microRNA precursor sequences.
Article in Biology direct, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- The PBX1/miR-141-miR-200a/EGR2/SOCS3 Axis; Integrative Analysis of Interaction Networks to Discover the Possible Mechanism of MiR-141 and MiR-200a-Mediated Th17 Cell Differentiation.Iranian journal of biotechnology · 2023Article
- Extracellular Vesicles from Red Blood Cells and Their Evolving Roles in Health, Coagulopathy and Therapy.International journal of molecular sciences · 2020Review
- TLR4-RelA-miR-30a signal pathway regulates Th17 differentiation during experimental autoimmune encephalomyelitis development.Journal of neuroinflammation · 2019Article
- Vitamin D stimulates multiple microRNAs to inhibit CRH and other pro-labor genes in human placenta.Endocrine connections · 2018Article
- Evidence for the association of chromatin and microRNA regulation in the human genome.Oncotarget · 2017Article
- Ancient human miRNAs are more likely to have broad functions and disease associations than young miRNAs.BMC genomics · 2017Article
- miRNA Enriched in Human Neuroblast Nuclei Bind the MAZ Transcription Factor and Their Precursors Contain the MAZ Consensus Motif.Frontiers in molecular neuroscience · 2017Article
- Article
- New Insight into microRNA Functions in Cancer: Oncogene-microRNA-Tumor Suppressor Gene Network.Frontiers in molecular biosciences · 2017Review
- Peroxisome Proliferator-Activated Receptor γ Regulates Chronic Alcohol-Induced Alveolar Macrophage Dysfunction.American journal of respiratory cell and molecular biology · 2016Article
- Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome.Journal of visualized experiments : JoVE · 2016Article
- Comprehensive Expression Profiling and Functional Network Analysis of p53-Regulated MicroRNAs in HepG2 Cells Treated with Doxorubicin.PloS one · 2016Article
- Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell.Scientific reports · 2015Article
- MicroRNA Regulation of Brain Tumour Initiating Cells in Central Nervous System Tumours.Stem cells international · 2015Review
- Mammalian Argonaute-DNA binding?Biology direct · 2014Article
- Therapeutic Opportunities for Targeting microRNAs in Cancer.Molecular and cellular therapies · 2014Article
- MicroRNAs in the Neural Retina.International journal of genomics · 2014Review
- A non-canonical landscape of the microRNA system.Frontiers in genetics · 2014Review
- Hypoxia: a master regulator of microRNA biogenesis and activity.Free radical biology & medicine · 2013Review
- Regulation of miRNA biogenesis as an integrated component of growth factor signaling.Current opinion in cell biology · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTranscription factors are thought to regulate the transcription of microRNA genes in a manner similar to that of protein-coding genes; that is, by binding to conventional transcription factor binding site DNA sequences located in or near promoter regions that lie upstream of the microRNA genes. However, in the course of analyzing the genomics of human microRNA genes, we noticed that annotated transcription factor binding sites commonly lie within 70- to 110-nt long microRNA small hairpin precursor sequences.
resultsWe report that about 45% of all human small hairpin microRNA (pre-miR) sequences contain at least one predicted transcription factor binding site motif that is conserved across human, mouse and rat, and this rises to over 75% if one excludes primate-specific pre-miRs. The association is robust and has extremely strong statistical significance; it affects both intergenic and intronic pre-miRs and both isolated and clustered microRNA genes. We also confirmed and extended this finding using a separate analysis that examined all human pre-miR sequences regardless of conservation across species.
conclusionsThe transcription factor binding sites localized within small hairpin microRNA precursor sequences may possibly regulate their transcription. Transcription factors may also possibly bind directly to nascent primary microRNA gene transcripts or small hairpin microRNA precursors and regulate their processing.
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