ArticleArthritis research & therapy2011
T cells as key players for bone destruction in gouty arthritis?
Article in Arthritis research & therapy, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Effect of n-3 PUFA on extracellular matrix protein turnover in patients with psoriatic arthritis: a randomized, double-blind, placebo-controlled trial.Rheumatology international · 2021Trial
- Increased circulating Th22 cells in patients with acute gouty arthritis: A CONSORT-compliant article.Medicine · 2017Trial
- Advancing Gouty Arthritis Research: The Clinical Value of Complete Blood Cell Count Ratios and Immune-Inflammatory Interactions.Journal of inflammation research · 2025Review
- Alterations in articular cartilage frictional properties in the setting of acute gouty arthritis.PloS one · 2024Article
- Upadacitinib sustained-release tablets for the treatment of chronic refractory gouty arthritis: a case report and literature review.Frontiers in medicine · 2024Article
- The Relationship Between Ambient Air Pollution and Hospitalizations for Gout in a Humid Subtropical Region of China.Journal of inflammation research · 2021Article
- Bone microstructure and volumetric bone mineral density in patients with hyperuricemia with and without psoriasis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2020Article
- The emerging role of biotechnological drugs in the treatment of gout.BioMed research international · 2014Review
- Inflammatory cells in tissues of gout patients and their correlations with comorbidities.The open rheumatology journal · 2013Article
- Effects of Extract from Mangifera indica Leaf on Monosodium Urate Crystal-Induced Gouty Arthritis in Rats.Evidence-based complementary and alternative medicine : eCAM · 2012Article
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5 authors.
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Abstract
The deposition of monosodium urate (MSU) crystals in synovial fluid and tissue leads to gouty arthritis frequently associated with synovial inflammation and bone erosions. The cellular mechanism that links MSU crystals to an increased number of osteoclasts has not yet been fully understood. In a recent issue of Arthritis Research & Therapy Lee and colleagues proposed that bone destruction in chronic gouty arthritis is at least in part dependent on expression by T cells of receptor activator of NF-κB ligand (RANKL). The authors showed that pro-resorptive cytokines such as IL-1β, IL-6, and TNFα are expressed within tophi and stromal infiltrates. In vitro stimulation with MSU crystals revealed monocytes as a source for these cytokines, whereas T cells produce RANKL, the major trigger of osteoclastogenesis.
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