Evidence map›Paper›PMID 22136149›Full record

SynthesisCNS drugs2012

Efficacy and safety of ketamine in patients with complex regional pain syndrome: a systematic review.

Pari Azari, David R Lindsay, Dean Briones, Collin Clarke, Thomas Buchheit, Srinivas Pyati

Registry-linked trialAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in CNS drugs, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02987855 (Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
6.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02987855 phase1 / phase2withdrawnnot on this mapstarted 2018, after this paper: background citation

Use of Autologous Adult Adipose-Derived Stem/Stromal Cells in Reflex Sympathetic Dystrophy (RSD), Complex Regional Pain Syndrome (CRPS), and Fibromyalgia

TypeinterventionalSponsorHealeon Medical IncRan2018 to 2024Enrolled0ConditionsRSD (Reflex Sympathetic Dystrophy), CRPS - Complex Regional Pain Syndrome Type I, FibromyalgiaArmsLipoaspiration, ADcSVF isolation, Normal Saline IV
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 88 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Guideline
  4. Trial
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Review
  10. Review
  11. Article
  12. Review
  13. A Review of Nonanesthetic Uses of Ketamine.Anesthesiology research and practice · 2020
    Review
  14. Article
  15. Review
  16. Review
  17. Article
  18. Treatment of Neuropathic Pain.Current treatment options in neurology · 2015
    Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Pari AzariDepartment of Anesthesiology, Division of Pain Management, Duke University School of Medicine, Durham, NC 27710, USA.
David R Lindsay
Dean Briones
Collin Clarke
Thomas Buchheit
Srinivas Pyati
Duke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Despite being a recognized clinical entity for over 140 years, complex regional pain syndrome (CRPS) remains a difficult-to-treat condition. While there have been multiple therapies explored in the treatment of CRPS, NMDA antagonists such as ketamine continue to hold significant interest because of their potential ability to alter the central sensitization noted in chronic pain states. The objective of this review is to identify published literature for evidence of the efficacy and safety of ketamine in the treatment of CRPS. PubMed and the Cochrane Controlled Trials Register were searched (final search 26 May 2011) using the MeSH terms 'ketamine', 'complex regional pain syndrome', 'analgesia' and 'pain' in the English literature. The manuscript bibliographies were then reviewed to identify additional relevant papers. Observational trials were evaluated using the Agency for Healthcare Research and Quality criteria; randomized trials were evaluated using the methodological assessment of randomized clinical trials. The search methodology yielded three randomized, placebo-controlled trials, seven observational studies and nine case studies/reports. In aggregate, the data available reveal ketamine as a promising treatment for CRPS. The optimum dose, route and timing of administration remain to be determined. Randomized controlled trials are needed to establish the efficacy and safety of ketamine and to determine its long-term benefit in CRPS.

Indexed as

Complex Regional Pain SyndromesExcitatory Amino Acid AntagonistsHumansKetamineExcitatory Amino Acid AntagonistsKetamine

Identifiers

PMID22136149
OpenAlexW1607364964

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.