ArticleThe Malaysian journal of medical sciences : MJMS2011
Spasmogenic Activity of the Seed of Terminalia chebula Retz in Rat Small Intestine: In Vivo and In Vitro Studies.
Article in The Malaysian journal of medical sciences : MJMS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Comparative evaluation of the potential anti-spasmodic activity ofSaudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Article
- Randomized Double-Blind Placebo-Controlled Supplementation with StandardizedJournal of clinical medicine · 2023Article
- Efficacy of Jawarish Shahi a herbal formulation in irritable bowel syndrome: An open-labeled single-arm clinical trial.Journal of traditional and complementary medicine · 2022Article
- Studies on antidiarrheal and laxative activities of aqueous-ethanol extract of Asphodelus tenuifolius and underlying mechanisms.BMC complementary and alternative medicine · 2019Article
- Herbal medicine use by pregnant women in Bangladesh: a cross-sectional study.BMC complementary and alternative medicine · 2018Article
- Efficacy of Sida pilosa Retz aqueous extract against Schistosoma mansoni - induced granulomatous inflammation in the liver and the intestine of mice: histomorphometry and gastrointestinal motility evaluation.BMC complementary and alternative medicine · 2018Article
- The development of Terminalia chebula Retz. (Combretaceae) in clinical research.Asian Pacific journal of tropical biomedicine · 2013Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTerminalia chebula Retz is traditionally used to relieve constipation. The current study was performed to investigate the pharmacological action of aqueous extract of Terminalia chebula seeds (ATC) in vitro and in vivo.
methodsTerminal pieces of rat ileum were suspended in organ bath containing Tyrode solution. The ileum spontaneous motility frequency and contractility were recorded isotonically. To induce ileal contraction, carbachol and ATC were added to the organ bath. In addition, the effect of hexamethonium, indomethacin, atropine, and verapamil on the ATC-induced ileal contractions was also investigated. The effectiveness of ATC on relieving morphine-induced constipation was investigated in an in vivo study by measuring the faecal number, faecal water content, and intestinal transit ratio.
resultsATC increased the frequency of ileum motility and tension of contraction dose-dependently (P < 0.05). Responses induced by ATC were inhibited by pre-treatment of the tissue with verapamil. The ATC activities were not affected by atropine, hexamethonium, and indomethacin. The faecal number and faecal water content were increased dose-dependently by ATC (P < 0.05).
conclusionThe excitatory effects of ATC on ileal contractile frequency and tension are possibly mediated through Ca(2+) channels activation. The results of the present study support the traditional usage of ATC for the treatment of constipation.
Indexed as
Identifiers
22135597PMC3216221W2410502513What OpenQuestion holds
Registered trials
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