ArticleThe Malaysian journal of medical sciences : MJMS2010
Evaluation of the antidiabetic and antilipaemic activities of the hydroalcoholic extract of phoenix dactylifera palm leaves and its fractions in alloxan-induced diabetic rats.
Article in The Malaysian journal of medical sciences : MJMS, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 51 citations in OpenAlex.
- Nutraceuticals ofDrug design, development and therapy · 2026Review
- Potential bioactivity of Phoenix dactylifera fruits, leaves, and seeds against prostate and pancreatic cancer cells.Frontiers in nutrition · 2022Article
- Commercial techniques for preserving date palm (Saudi journal of biological sciences · 2021Review
- Middle East Medicinal Plants in the Treatment of Diabetes: A Review.Molecules (Basel, Switzerland) · 2021Review
- Date palm fruit extract ameliorated pancreatic apoptosis, endocrine dysfunction and regulatory inflammatory cytokines in Streptozotocin-induced diabetes in rats.Environmental science and pollution research international · 2020Article
- Potentials and Safety of Date Palm Fruit against Diabetes: A Critical Review.Foods (Basel, Switzerland) · 2020Review
- Antioxidant Effects and Mechanisms of Medicinal Plants and Their Bioactive Compounds for the Prevention and Treatment of Type 2 Diabetes: An Updated Review.Oxidative medicine and cellular longevity · 2020Review
- Antidiabetic Potential of Medicinal Plants and Their Active Components.Biomolecules · 2019Review
- Antidiabetic plant-derived nutraceuticals: a critical review.European journal of nutrition · 2018Review
- Therapeutic effects of date fruits (Phoenix dactylifera) in the prevention of diseases via modulation of anti-inflammatory, anti-oxidant and anti-tumour activity.International journal of clinical and experimental medicine · 2014Review
- Diabetes mellitus: an overview on its pharmacological aspects and reported medicinal plants having antidiabetic activity.Asian Pacific journal of tropical biomedicine · 2012Review
- Glucose-lowering potential ofAvicenna journal of phytomedicineArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe antidiabetic and antilipaemic effects of Phoenix dactylifera leaf extract (PDE) and its fractions were investigated in various rat models.
methodsDiabetes was induced in male Wistar rats by alloxan monohydrate. Diabetic animals were randomly divided into 8 groups (1 diabetic control and 7 treated groups). Diabetic control animals received saline (5 mL/kg) orally, whereas the treatment groups received different doses of PDE (100, 200, and 400 mg/kg), PDE fractions (50, 100, and 200 mg/kg), or glibenclamide (4 mg/kg) orally once a day for 14 days. Blood was withdrawn for glucose determination on the 1(st), 6(th), 10(th), and 14(th) days. The rats were fasted overnight and then sacrificed on the 14(th) day; blood was collected for biochemical evaluation, including the levels of blood glucose, plasma insulin, serum triglyceride, and cholesterol.
resultsSubacute administration of PDE or its fractions in alloxan-induced diabetic rats significantly reduced blood glucose (P < 0.01). Water intake, serum triglyceride, and cholesterol also decreased in treated animals compared with the control group (P < 0.01). Plasma insulin level increased in the treated groups relative to the control group (P < 0.01).
conclusionThe results suggested that PDE exhibits antidiabetic and antilipaemic effects in alloxan-induced diabetic rats.
Indexed as
Identifiers
22135555PMC3216186W2405179651What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.