Evidence map›Paper›PMID 22135492›Full record

ArticleInternational journal of chronic obstructive pulmonary disease2011

Asthma, chronic obstructive pulmonary disease, or both? Diagnostic labeling and spirometry in primary care patients aged 40 years or more.

Hasse Melbye, Elin Drivenes, Lene G Dalbak, Tone Leinan, Svein Høegh-Henrichsen, Anders Ostrem

Registry-linked trialAbstract read
In one paragraph

Article in International journal of chronic obstructive pulmonary disease, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03137303 (Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma), which is not on this map. Cited by 22 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03137303 phase3completednot on this mapstarted 2017, after this paper: background citation

Reducing Diagnostic Error to Improve Patient Safety in COPD and Asthma (REDEFINE Study)

TypeinterventionalSponsorUniversity of Illinois at ChicagoRan2017 to 2019Enrolled402ConditionsCOPD AsthmaArmsSpirometry at initial visit, Albuterol, Spirometry at 12-month follow-up
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Concomitant diagnosis of asthma and COPD: a quantitative study in UK primary care.The British journal of general practice : the journal of the Royal College of General Practitioners · 2018
    Article
  6. Article
  7. Article
  8. Article
  9. Drop in lung function during asthma and COPD exacerbations - can it be assessed without spirometry?International journal of chronic obstructive pulmonary disease · 2016
    Observational
  10. Article
  11. Article
  12. Addressing unmet needs in the treatment of COPD.European respiratory review : an official journal of the European Respiratory Society · 2014
    Review
  13. AIMAR survey on COPD phenotypes.Multidisciplinary respiratory medicine · 2014
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Over diagnosis of chronic obstructive pulmonary disease in an underserved patient population.International journal of chronic obstructive pulmonary disease · 2013
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hasse MelbyeGeneral Practice Research Unit, Department of Community Medicine, University of Tromsø, Norway. hasse.melbye@uit.no
Elin Drivenes
Lene G Dalbak
Tone Leinan
Svein Høegh-Henrichsen
Anders Ostrem

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo describe symptoms and lung function in patients registered with asthma or chronic obstructive pulmonary disease (COPD) in primary care and to examine how spirometry findings fit with general practitioners' (GPs) diagnoses.

methodsPatients aged ≥40 years with a diagnosis of asthma or COPD registered in the electronic medical record during the previous 5 years were recruited at seven GP offices in Norway in 2009-2010. Registered diagnosis, spirometry results, comorbidity, and reported symptoms were compared.

resultsAmong 376 patients, 62% were women. Based on Global Initiative for Chronic Obstructive Lung Diseases criteria, a spirometry diagnosis of COPD could be made in 68.1% of the patients with a previous COPD diagnosis and in 17.1% of those diagnosed with asthma only (P < 0.001). The κ agreement between last clinical diagnosis of COPD and COPD based on spirometry was 0.50. A restrictive spirometry pattern was found in 19.4% and more frequently in patients diagnosed with both asthma and COPD (23.9%) than in patients diagnosed with COPD only (6.8%, P = 0.003).

conclusionThe ability of GPs to differentiate between asthma and COPD seems to have considerably improved during the last decade, probably due to the dissemination of spirometry and guidelines for COPD diagnosis. A diagnosis of COPD that cannot be confirmed by spirometry represents a challenge in clinical practice, in particular when a restrictive pattern on spirometry is found.

Indexed as

Primary Health CareSpirometryAdultAgedAge FactorsAsthmaChi-Square DistributionComorbidityDiagnosis, DifferentialFemaleForced Expiratory VolumeHumansLungMaleMiddle AgedNorwayasthmaCOPDdiagnosisprimary care

Identifiers

PMID22135492
PMCPMC3224654

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.