ArticleCirculation. Heart failure2012
Akt1-mediated skeletal muscle growth attenuates cardiac dysfunction and remodeling after experimental myocardial infarction.
Article in Circulation. Heart failure, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 51 citations in OpenAlex.
- Identification of Bioactive Ingredients and Mechanistic Pathways of Xuefu Zhuyu Decoction in Ventricular Remodeling: A Network Pharmacology, Molecular Docking and Molecular Dynamics Simulations.Current pharmaceutical design · 2026Article
- Echocardiographic Alterations in Subjects with Sarcopenia and Right Heart Failure.Medical sciences (Basel, Switzerland) · 2025Article
- The associations of calf circumference and cardiovascular and all-cause mortality among population with chronic kidney disease stages 3-5.Scientific reports · 2025Article
- Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury.PloS one · 2025Article
- Exploring the Mechanism of Action of Berberine on Arrhythmia After Myocardial Infarction: A Network Pharmacology, Molecular Docking, and Cellular Experimental Study.Cardiovascular therapeutics · 2025Article
- Mineralocorticoid Receptor Blocker Prevents Mineralocorticoid Receptor-Mediated Inflammation by Modulating Transcriptional Activity of Mineralocorticoid Receptor-p65-Signal Transducer and Activator of Transcription 3 Complex.Journal of the American Heart Association · 2024Article
- Article
- Relationship between high-sensitivity cardiac troponin T, B-type natriuretic peptide, and physical function in patients with heart failure.ESC heart failure · 2021Article
- A simple method of sarcopenia detection can predict adverse cardiovascular events in patients with abdominal obesity.International journal of obesity (2005) · 2021Article
- Review
- Cardioprotective Effects of Rivaroxaban on Cardiac Remodeling After Experimental Myocardial Infarction in Mice.Circulation reports · 2020Article
- Musclin, A Myokine Induced by Aerobic Exercise, Retards Muscle Atrophy During Cancer Cachexia in Mice.Cancers · 2019Article
- Buyang Huanwu Decoction Exerts Cardioprotective Effects through Targeting Angiogenesis via Caveolin-1/VEGF Signaling Pathway in Mice with Acute Myocardial Infarction.Oxidative medicine and cellular longevity · 2019Article
- RNA-seq and metabolomic analyses of Akt1-mediated muscle growth reveals regulation of regenerative pathways and changes in the muscle secretome.BMC genomics · 2017Article
- Aerobic training and l-arginine supplementation promotes rat heart and hindleg muscles arteriogenesis after myocardial infarction.Journal of physiology and biochemistry · 2016Article
- Exendin-4 induces myocardial protection through MKK3 and Akt-1 in infarcted hearts.American journal of physiology. Cell physiology · 2016Article
- Asiatic acid inhibits left ventricular remodeling and improves cardiac function in a rat model of myocardial infarction.Experimental and therapeutic medicine · 2016Article
- OSM Enhances Angiogenesis and Improves Cardiac Function after Myocardial Infarction.BioMed research international · 2015Article
- Akt1-mediated fast/glycolytic skeletal muscle growth attenuates renal damage in experimental kidney disease.Journal of the American Society of Nephrology : JASN · 2014Article
- Discovery and refinement of muscle weight QTLs in B6 × D2 advanced intercross mice.Physiological genomics · 2014Article
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIt is appreciated that aerobic endurance exercise can attenuate unfavorable myocardial remodeling following myocardial infarction. In contrast, little is known about the effects of increasing skeletal muscle mass, typically achieved through resistance training, on this process. Here, we utilized transgenic (TG) mice that can induce the growth of functional skeletal muscle by switching Akt1 signaling in muscle fibers to assess the impact of glycolytic muscle growth on post-myocardial infarction cardiac remodeling. METHODS AND
resultsMale-noninduced TG mice and their nontransgenic littermates (control) were subjected to left anterior coronary artery ligation. Two days after surgery, mice were provided doxycycline in their drinking water to activate Akt1 transgene expression in a skeletal muscle-specific manner. Myogenic Akt1 activation led to diminished left ventricular dilation and reduced contractile dysfunction compared with control mice. Improved cardiac function in Akt1 TG mice was coupled to diminished myocyte hypertrophy, decreased interstitial fibrosis, and increased capillary density. ELISA and protein array analyses demonstrated that serum levels of proangiogenic growth factors were upregulated in Akt1 TG mice compared with control mice. Cardiac eNOS was activated in Akt1 TG mice after myocardial infarction. The protective effect of skeletal muscle Akt activation on cardiac remodeling and systolic function was abolished by treatment with the eNOS inhibitor l-NAME.
conclusionsAkt1-mediated skeletal muscle growth attenuates cardiac remodeling after myocardial infarction and is associated with an increased capillary density in the heart. This improvement appears to be mediated by skeletal muscle to cardiac communication, leading to activation of eNOS-signaling in the heart.
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